ArticleCell reports2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8
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Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
What it found
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Activated PIK3CD drives marginal zone B cell development from early transitional progenitors by enhancing ADAM10 expression.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation.The Journal of experimental medicine · 2026Article
- CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency.Nature cancer · 2026Article
- The epigenetic-immune-microbiome axis in early life: reprogramming the origins and endotypes of pediatric asthma.Frontiers in immunology · 2026Review
- Dimethyl Sulfoxide Modulates T Cell-Mediated Immunity to Attenuate Influenza A Virus Infection.Journal of inflammation research · 2026Article
- Senescent B cells regulate CD38 expression via FOXO1 in pneumonia resulting fromLife medicine · 2025Article
- PI3K GOF leads to dysregulation of T and B cells that both contribute to extrinsically driving activation and differentiation of other CD4Immunology and cell biology · 2025Article
- Immune regeneration: implications for cancer immunotherapy and beyond.The Journal of clinical investigation · 2025Review
- A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8Nature metabolism · 2025Article
- The multifaceted roles of TCF1 in innate and adaptive lymphocytes.Advances in immunology · 2024Review
- Technical challenges of intracellular flow cytometry-based assays as a functional complement to diagnosis of signaling defects of inborn errors of immunity: PI3K pathway as a case of study.Frontiers in immunology · 2024Article
- PI3Kδ Pathway Dysregulation and Unique Features of Its Inhibition by Leniolisib in Activated PI3Kδ Syndrome and Beyond.The journal of allergy and clinical immunology. In practice · 2024Article
- Engineering metabolism to modulate immunity.Advanced drug delivery reviews · 2024Review
- Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells.Cell reports · 2023Article
- ANCA vasculitis expands the spectrum of autoimmune manifestations of activated PI3 kinase δ syndrome.Frontiers in pediatrics · 2023Review
- Molecular and temporal control of restimulation-induced cell death (RICD) in T lymphocytes.Frontiers in cell death · 2023Article
- Hierarchical transcriptional network governing heterogeneous T cell exhaustion and its implications for immune checkpoint blockade.Frontiers in immunology · 2023Review
- Cutting Edge: Promoting T Cell Factor 1Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- The Road Less Taken: Less Appreciated Pathways for Manipulating CD8Frontiers in immunology · 2022Review
- Review
Corrections and comments
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Authors and funding
20 authors at 5 institutions in 1 country.
Jennifer L CannonsNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Electronic address: jcannons@mail.nih.gov.
Alejandro V VillarinoNational Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA; Department of Microbiology & Immunology and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Senta M KapnickNational Human Genome Research Institute, NIH, Bethesda, MD 20892, USA; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Silvia PreiteNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Han-Yu ShihNational Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA; National Eye Institute, NIH, Bethesda, MD 20892, USA.
Julio Gomez-RodriguezNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA; TCR2 Therapeutics, Cambridge, MA 02142, USA.
Zenia KaulNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Hirofumi ShibataNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Julie M ReilleyNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Bonnie HuangNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Robin HandonNational Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Ian T McBainNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Selamawit GossaNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA.
Tuoqi WuNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA; University of Colorado, Department of Immunology, Denver, CO 80204, USA; Department of Immunology and Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390.
Helen C SuNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Dorian B McGavernNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA.
John J O'SheaNational Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Peter J McGuireNational Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Gulbu UzelNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Pamela L SchwartzbergNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Electronic address: pams@nih.gov.
National Human Genome Research Institute · USNational Institute of Allergy and Infectious Diseases · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USNational Institute of Neurological Disorders and Stroke · USUniversity of Miami · US
Funding
Genetic and Biochemical Approaches to Tyrosine Kinase and Lymphocyte SignalingZIAAI001240 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SCHWARTZBERG, PAMELA · 2019 to 2025
$18.8MIntramural NIH HHS ZIA AI001240
Abstract
Patients with activated phosphatidylinositol 3-kinase delta (PI3Kδ) syndrome (APDS) present with sinopulmonary infections, lymphadenopathy, and cytomegalvirus (CMV) and/or Epstein-Barr virus (EBV) viremia, yet why patients fail to clear certain chronic viral infections remains incompletely understood. Using patient samples and a mouse model (Pik3cd
Indexed as
Chromatin Assembly and DisassemblyImmunologic MemoryTranscription, GeneticAdolescentAdultAnimalsApoptosisCase-Control StudiesCD8-Positive T-LymphocytesChildChromatinClass I Phosphatidylinositol 3-KinasesDisease Models, AnimalEnzyme ActivationFas Ligand ProteinFemaleChromatinClass I Phosphatidylinositol 3-KinasesFASLG protein, humanFas Ligand ProteinFasl protein, mousePIK3CD protein, humanPik3cd protein, mouseapoptosisCD8 T cell memoryeffector T cellsIL-2long-lived effector cells (LLEC)metabolismmTORMycPhosphatidylinositide 3 Kinase delta (PI3Kδ)TCF1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.