ArticleCell2021
A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development.
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Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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68citing papers in PubMed
25.0field-weighted citation impact, top 1% of its field
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Who cites it
68 citing papers in PubMed, 117 citations in OpenAlex.
- Dual effect of α-synuclein disease variants on condensate formation.Nature communications · 2026Article
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- An ancient retrotransposon provides species-specific tuning of IL-18 inflammatory signaling.bioRxiv : the preprint server for biology · 2026Article
- TBP regulates transposable element expression in early mouse embryos.The EMBO journal · 2026Article
- Single-oocyte full-length isoform sequencing unveils the impact of transposable elements on RNA diversity and stability.Nature communications · 2026Article
- Polycomb repressive-deubiquitinase complex safeguards oocyte epigenome and female fertility by restraining Polycomb activity.Nature communications · 2026Article
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- Architectural and evolutionary features of TE-derived TSSs shape tissue-specific promoter activity in the human genome.Nature communications · 2026Article
- Expression spectrum of TE-driven transcripts in human adult tissues.Genome biology · 2026Article
- TEITbase: a database for transposable element (TE)-initiated transcripts in human cancers.Database : the journal of biological databases and curation · 2026Article
- CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death.Science advances · 2025Article
- Major waves of H2A.Z incorporation during mouse oogenesis and preimplantation embryo development.Nature communications · 2025Article
- Molecular effects of transposable element sequences in mammalian cells.Genome biology · 2025Review
- Transposable elements drive species-specific and tissue-specific transcriptomes in human development.Genome biology · 2025Article
- Article
- Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds.The EMBO journal · 2025Article
- Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease.Nature reviews. Molecular cell biology · 2025Review
- Transposable elements in health and disease: Molecular basis and clinical implications.Chinese medical journal · 2025Review
- Transposable elements as instructors of the immune system.Nature reviews. Immunology · 2025Review
- Transposable element expression and sub-cellular dynamics during hPSC differentiation to endoderm, mesoderm, and ectoderm lineages.Nature communications · 2025Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 6 institutions in 4 countries.
Andrew J ModzelewskiDivision of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.
Wanqing ShaoDepartment of Genetics, Edison Family Center for Genome Science and System Biology, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jingqi ChenDivision of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.
Angus LeeDivision of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.
Xin QiDivision of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.
Mackenzie NoonDivision of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.
Kristy TjokroDivision of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.
Gabriele SalesDepartment of Biology, University of Padova, Padova 35122, Italy.
Anne BitonDepartment of Statistics, University of California, Berkeley, Berkeley, CA 94720, USA; Bioinformatics and Biostatistics, Department of Computational Biology, USR 3756 CNRS, Institut Pasteur, Paris 75015, France.
Aparna AnandDepartment of Genetics, Edison Family Center for Genome Science and System Biology, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.
Terence P SpeedBioinformatics Division, WEHI, Parkville, VIC 3052, Australia.
Zhenyu XuanDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Ting WangDepartment of Genetics, Edison Family Center for Genome Science and System Biology, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: twang@wustl.edu.
Davide RissoDepartment of Statistical Sciences, University of Padova, Padova 35122, Italy. Electronic address: davide.risso@unipd.it.
Lin HeDivision of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: lhe@berkeley.edu.
University of California, Berkeley · USUniversity of Padua · ITWashington University in St. Louis · USCentre National de la Recherche Scientifique · FRMcGill Genome Centre · CAThe University of Texas at Dallas · US
Funding
The WashU-UCSC-EBI Human Genome Reference Center."U41HG010972 · NHGRI · WASHINGTON UNIVERSITY · PI Ting Wang · 2019 to 2026
$24.9MGENCODE: comprehensive reference genome annotation for human and mouseU24HG007234 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI Fergal James Martin · 2021 to 2026
$16.1MWashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating CenterU24HG012070 · NHGRI · WASHINGTON UNIVERSITY · PI Ting Wang, Feng Yue · 2021 to 2026
$9.7MCancer Genomics:Integrative and Scalable Solutions in R / BioconductorU24CA180996 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MORGAN, MARTIN T, WALDRON, LEVI · 2014 to 2023
$6.9MTHE WASHU TARGET ENVIRONMENTAL EPIGENOMICS DATA COORDINATION CENTERU24ES026699 · NIEHS · WASHINGTON UNIVERSITY · PI WANG, TING · 2016 to 2021
$5.2MRESEARCH EDUCATION PROGRAM ON COMPUTATIONAL AND STATISTICAL TOOL DEVELOPMENT FOR ADDICTION GENETICSR25DA027995 · NIDA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN, RICE, JOHN P. · 2009 to 2019
$4.3MmiR-200 miRNAs repress tumor metastasis in lung adenocarcinomaR01CA139067 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HE, LIN · 2009 to 2021
$3.3MDECODING THE IMPACT OF TRANSPOSABLE ELEMENTS ON GENE REGULATIONR01HG007175 · NHGRI · WASHINGTON UNIVERSITY · PI WANG, TING · 2014 to 2021
$2.7MChoroid Plexus Multi-Sensory Cilia Regulate Production of Cerebrospinal FluidR01NS120287 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HE, LIN · 2021 to 2025
$2.5MConnecting transposable elements and regulatory innovation using ENCODE dataU01HG009391 · NHGRI · WASHINGTON UNIVERSITY · PI COHEN, BARAK A, FESCHOTTE, CEDRIC · 2017 to 2021
$2.4MThe WashU 4DN Network Data Coordination and Integration CenterU01CA200060 · NCI · WASHINGTON UNIVERSITY · PI WANG, TING · 2015 to 2019
$1.9MRole of Brg1 in Activity-Induced Neuronal Gene Expression and Synaptic PlasticityR01NS096068 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI WU, JIANG · 2016 to 2020
$1.8MHoward Hughes Medical InstituteNCI NIH HHS R01 CA139067NCI NIH HHS U01 CA200060NCI NIH HHS U24 CA180996NHGRI NIH HHS R01 HG007175NHGRI NIH HHS U01 HG009391NHGRI NIH HHS U24 HG007234NHGRI NIH HHS U24 HG012070NHGRI NIH HHS U41 HG010972NICHD NIH HHS K99 HD096108NIDA NIH HHS R25 DA027995NIEHS NIH HHS U24 ES026699NIGMS NIH HHS R01 GM114414NIH HHS R21 OD027053NINDS NIH HHS R01 NS096068NINDS NIH HHS R01 NS120287NINDS NIH HHS R21 NS099761
Abstract
Retrotransposons mediate gene regulation in important developmental and pathological processes. Here, we characterized the transient retrotransposon induction during preimplantation development of eight mammals. Induced retrotransposons exhibit similar preimplantation profiles across species, conferring gene regulatory activities, particularly through long terminal repeat (LTR) retrotransposon promoters. A mouse-specific MT2B2 retrotransposon promoter generates an N-terminally truncated Cdk2ap1
Indexed as
Conserved SequenceAnimalsBase SequenceBlastocystCell ProliferationEmbryonic DevelopmentEvolution, MolecularFemaleGene Expression Regulation, DevelopmentalHuman Embryonic Stem CellsHumansMammalsMiceMice, Inbred C57BLMice, KnockoutModels, BiologicalCdk2ap1 protein, mouseProtein IsoformsProtein KinasesRetroelementsTumor Suppressor ProteinsCdk2Cdk2ap1cell proliferationimplantationmammalsmousepreimplantation embryospromotersretrotransposonstransposons
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