Evidence map›Paper›PMID 34644455›Full record

ArticlePediatric pulmonology2022

Successful whole lung lavage in a child with pulmonary alveolar proteinosis secondary to hematologic malignancy.

Katharine Tsukahara, Robert B Lindell, Haley Newman, Benjamin J Lerman, Leslie S Kersun, Joseph Piccione

Open access · greenAbstract readCase Reports
In one paragraph

Article in Pediatric pulmonology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Katharine TsukaharaDivision of Pulmonary and Sleep Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-2115-5944
Robert B LindellDivision of Critical Care Medicine, Department of Anesthesia and Critical Care, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-6334-4973
Haley NewmanDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3022-8052
Benjamin J LermanDivision of General Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Leslie S KersunDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Joseph PiccioneDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-0691-3551
Children's Hospital of Philadelphia · US

Funding

CANCER RESEARCH TRAINING PROGRAMT32CA009615 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Gregory L Beatty, MICHAEL D HOGARTY · 1988 to 2026
$10.4M
Postdoctoral Training Program in Genomic MedicineT32HG009495 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI Katherine L. Nathanson, Bogdan Pasaniuc · 2017 to 2026
$4.2M
NCI NIH HHS T32 CA009615NHGRI NIH HHS T32 HG009495
6 · The paper itself

Abstract

Pulmonary alveolar proteinosis (PAP) describes the accumulation of surfactant in the alveolar space. Secondary PAP has been reported in a variety of diseases, and in rare cases has been associated with hematologic malignancy. Treatment for PAP is based on the underlying disease process, and may include whole lung lavage, inhaled or subcutaneous granulocyte-macrophage colony-stimulating factor, or statins. PAP secondary to hematologic malignancy has been reported to demonstrate poor response to whole lung lavage. We report a case of successful treatment of a pediatric patient with acute myeloid leukemia and secondary PAP using whole lung lavage.

Indexed as

Hematologic NeoplasmsHydroxymethylglutaryl-CoA Reductase InhibitorsPulmonary Alveolar ProteinosisPulmonary SurfactantsBronchoalveolar LavageChildHumansHydroxymethylglutaryl-CoA Reductase InhibitorsPulmonary Surfactantsacute myeloid leukemiabronchoscopypulmonary surfactant

Identifiers

PMID34644455
PMCPMC8665118
OpenAlexW3206532495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.