Evidence map›Paper›PMID 34644263›Full record

ArticleAging2021

Cosmc transfection decreases malignant behavior of Tn

Ruisong Ding, Xingyou Hu, Wen Hu, Zhenzhen Du, Panpan Huang, Mengyang Wang, Jiaoyue Sheng, Yanchao Ma, Ailing Wang, Xiying Luan and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Ruisong DingDepartment of Immunology, Binzhou Medical University, Yantai 264003, PR China.
Xingyou HuQingdao University, Qingdao 266071, PR China.
Wen HuDepartment of Immunology, Binzhou Medical University, Yantai 264003, PR China.
Zhenzhen DuDepartment of Immunology, Binzhou Medical University, Yantai 264003, PR China.
Panpan HuangDepartment of Immunology, Binzhou Medical University, Yantai 264003, PR China.
Mengyang WangDepartment of Immunology, Binzhou Medical University, Yantai 264003, PR China.
Jiaoyue ShengDepartment of Oncology, Qingdao No.6 People's Hospital, Qingdao 266033, PR China.
Yanchao MaDepartment of Immunology, Binzhou Medical University, Yantai 264003, PR China.
Ailing WangLaboratory Department, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong Province 264100, PR China.
Xiying LuanDepartment of Immunology, Binzhou Medical University, Yantai 264003, PR China.
Menghua DongDepartment of Immunology, Binzhou Medical University, Yantai 264003, PR China.
Qizhi CaoDepartment of Immunology, Binzhou Medical University, Yantai 264003, PR China.
Yanfen ZouDepartment of Obstetrics and Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, PR China.
Tao HuDepartment of Immunology, Binzhou Medical University, Yantai 264003, PR China.
Binzhou Medical University · CNBinzhou University · CNQingdao Eighth People's Hospital · CNQingdao University · CNYuhuangding Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cosmc mutations may cause abnormal O-glycosylation and result in Tn antigen expression. In the current study, it was discovered that proliferation and migration of Tn+ cells (Jurkat T and LS174T-Tn

Indexed as

Antigens, Tumor-Associated, CarbohydrateApoptosisCell Line, TumorGlycosylationHumansJurkat CellsMolecular ChaperonesMutationPlasmidsPolysaccharidesTNF-Related Apoptosis-Inducing LigandTransfectionAntigens, Tumor-Associated, CarbohydrateC1GALT1C1 protein, humanMolecular ChaperonesPolysaccharidesTn antigenTNF-Related Apoptosis-Inducing LigandTNFSF10 protein, humanApo2L/TRAILapoptosisC3GnTCosmcO-glycosylationTn antigen

Identifiers

PMID34644263
PMCPMC8549606
OpenAlexW3207098900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.