Evidence map›Paper›PMID 34644153›Full record

ReviewAnnual review of medicine2022

Organoid Models for Infectious Disease.

Sarah E Blutt, Mary K Estes

Abstract readReview
In one paragraph

Review in Annual review of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Animal organoids as models for integrated One Health research.One health (Amsterdam, Netherlands) · 2026
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  2. Article
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  4. Advances in vascularized organoids.Chinese medical journal · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sarah E BluttDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA; email: mestes@bcm.edu.
Mary K EstesDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA; email: mestes@bcm.edu.

Funding

X-ray Crystallographic Studies on CalicivirusesP01AI057788 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI PRASAD, BIDADI VENKATARAM · 2004 to 2024
$34.4M
Viral Diversity and Pathogenicity in Mucosal Respiratory and Gastrointestinal DiseaseU19AI144297 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MARESSO, ANTHONY W · 2019 to 2024
$30.1M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Novel Platforms for Human Intestinal Enteroids: Matrix, Mechanics, and TopographyU19AI116497 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BLUTT, SARAH E · 2015 to 2025
$13.2M
Intestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5M
Intestinal Stem Cell Response to InfectionU01DK103168 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI ESTES, MARY KOLB · 2014 to 2023
$4.2M
Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3M
NIAID NIH HHS P01 AI057788NIAID NIH HHS U19 AI116497NIAID NIH HHS U19 AI144297NIDDK NIH HHS P30 DK056338NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U01 DK103168NIDDK NIH HHS U24 DK085532
6 · The paper itself

Abstract

Infectious diseases affect individual health and have widespread societal impacts. New ex vivo models are critical to understand pathogenesis, host response, and features necessary to develop preventive and therapeutic treatments. Pluripotent and tissue stem cell-derived organoids provide new tools for the study of human infections. Organoid models recapitulate many characteristics of in vivo disease and are providing new insights into human respiratory, gastrointestinal, and neuronal host-microbe interactions. Increasing culture complexity by adding the stroma, interorgan communication, and the microbiome will improve the use of organoids as models for infection. Organoid cultures provide a platform with the capability to improve human health related to infectious diseases.

Indexed as

Communicable DiseasesOrganoidsHumansinfectionorganoidpathogenesisstem celltherapies

Identifiers

PMID34644153
PMCPMC8887824

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.