Evidence map›Paper›PMID 34644092›Full record

ArticleJournal of natural products2021

Mining of the

Jincai Liang, Tianyue An, Jian-Xun Zhu, Shan Chen, Jian-Hua Zhu, Reuben J Peters, Rongmin Yu, Jiachen Zi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Microbial production of 5-Applied and environmental microbiology · 2024
    Article
  2. Review
  3. Hedycaryol - Central Intermediates in Sesquiterpene Biosynthesis, Part II.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jincai LiangBiotechnological Institute of Chinese Materia Medic, Jinan University, Guangzhou 510632, China.
Tianyue AnBiotechnological Institute of Chinese Materia Medic, Jinan University, Guangzhou 510632, China.
Jian-Xun ZhuBiotechnological Institute of Chinese Materia Medic, Jinan University, Guangzhou 510632, China.
Shan ChenBiotechnological Institute of Chinese Materia Medic, Jinan University, Guangzhou 510632, China.
Jian-Hua ZhuBiotechnological Institute of Chinese Materia Medic, Jinan University, Guangzhou 510632, China.
Reuben J PetersRoy J. Carver Department of Biochemistry, Biophysics, Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.ORCID 0000-0003-4691-8477
Rongmin YuBiotechnological Institute of Chinese Materia Medic, Jinan University, Guangzhou 510632, China.ORCID 0000-0002-2589-558X
Jiachen ZiBiotechnological Institute of Chinese Materia Medic, Jinan University, Guangzhou 510632, China.ORCID 0000-0002-0212-1282

Funding

Purchase of replacement GC-MS for Peters R35/MIRA (GM131885)R35GM131885 · NIGMS · IOWA STATE UNIVERSITY · PI PETERS, REUBEN JOHN · 2019 to 2023
$2.6M
NIGMS NIH HHS R35 GM131885
6 · The paper itself

Abstract

Characterization of cryptic biosynthetic gene clusters (BGCs) from microbial genomes has been proven to be a powerful approach to the discovery of new natural products. However, such a genome mining approach to the discovery of bioactive plant metabolites has been muted. The plant BGCs characterized to date encode pathways for antibiotics important in plant defense against microbial pathogens, providing a means to discover such phytoalexins by mining plant genomes. Here is reported the discovery and characterization of a minimal BGC from the medicinal plant

Indexed as

Multigene FamilyAlkyl and Aryl TransferasesCatharanthusCytochrome P-450 Enzyme SystemFungicides, IndustrialGenome, PlantPhytoalexinsPlant DiseasesPlants, MedicinalSesquiterpenesZea maysAlkyl and Aryl TransferasesCytochrome P-450 Enzyme SystemFungicides, IndustrialPhytoalexinsSesquiterpenesterpene synthase

Identifiers

PMID34644092
PMCPMC8627374

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.