Evidence map›Paper›PMID 34643942›Full record

ArticleHealth services research2022

Influence function methods to assess the effectiveness of influenza vaccine with survey data.

Mingmei Tian, Jihnhee Yu, Denise F Lillvis, Albert Vexler

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Article in Health services research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Mingmei TianDepartment of Biostatistics, University at Buffalo, State University of New York, Buffalo, New York, USA.
Jihnhee YuDepartment of Biostatistics, University at Buffalo, State University of New York, Buffalo, New York, USA.ORCID 0000-0002-6866-5928
Denise F LillvisDepartment of Surgery, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
Albert VexlerDepartment of Biostatistics, University at Buffalo, State University of New York, Buffalo, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine a robust relative risk (RR) estimation for survey data analysis with ideal inferential properties under various model assumptions. DATA SOURCES: We employed secondary data from the Household Component of the 2000-2016 US Medical Expenditure Panel Survey (MEPS). STUDY

designWe investigate a broad range of data-balancing techniques by implementing influence function (IF) methods, which allows us to easily estimate the variability for the RR estimates in the complex survey setting. We conduct a simulation study of seasonal influenza vaccine effectiveness to evaluate these approaches and discuss techniques that show robust inferential performance across model assumptions. DATA COLLECTION/EXTRACTION

methodsDemographic information, vaccine status, and self-administered questionnaire surveys were obtained from the longitudinal data files. We linked this information with medical condition files and medical event to extract the disease type and associated expenditures for each medical visit. We excluded individuals who were 18 years or younger at the beginning of each panel. PRINCIPAL

findingsUnder various model assumptions, the IF methods show robust inferential performance when the data-balancing procedures are incorporated. Once IF methods and data-balancing techniques are implemented, contingency table-based RR estimation yields a comparable result to the generalized linear model approach. We demonstrate the applicability of the proposed methods for complex survey data using 2000-2016 MEPS data. When employing these methods, we find a significant, negative association between vaccine effectiveness (VE) estimates and influenza-incurred expenditures.

conclusionsWe describe and demonstrate a robust method for RR estimation and relevant inferences for influenza vaccine effectiveness using MEPS data. The proposed method is flexible and can be extended to weighted data for survey data analysis. Hence, these methods have great potential for health services research, especially when data are nonexperimental and imbalanced.

Indexed as

Computer SimulationAdultAgedCase-Control StudiesEpidemicsFemaleHumansInfluenza, HumanInfluenza VaccinesMaleMiddle AgedResearch DesignRisk FactorsInfluenza Vaccinesbiostatistical methodshealthcare surveysinfluenza vaccinesmedical expendituresrisk assessment

Identifiers

PMID34643942
PMCPMC8763297

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