Evidence map›Paper›PMID 34643929›Full record

ArticleMolecular biology reports2021

Curcumin inhibition of bleomycin-induced changes in lung collagen synthesis, deposition and assembly.

Punithavathi Durairaj, Santosh Venkatesan, Venkatesan Narayanan, Mary Babu

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Punithavathi DurairajDepartment of Biotechnology, Central Leather Research Institute, Chennai, India.
Santosh VenkatesanBiology Department, Concordia University, Montreal, Canada.
Venkatesan NarayananDepartment of Biochemistry, Central Leather Research Institute, Chennai, India. vnar12@yahoo.com.ORCID http://orcid.org/0000-0003-0272-9797
Mary BabuDepartment of Biotechnology, Central Leather Research Institute, Chennai, India.
Central Leather Research Institute · INConcordia University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdiopathic pulmonary fibrosis is characterized by progressive lung tissue remodeling and disproportionate deposition of collagenous proteins with limited therapeutic interventions. The purpose of this study was to determine whether curcumin inhibits bleomycin (BLM)-induced increases in synthesis, degradation and cross-linking of lung collagen in rats. METHODS AND

resultsFollowing a single intratracheal instillation of BLM to rats (0.75 U/100 g, sacrificed 3, 5, 7, 14 and 28 days post-BLM), lung collagen synthesis (determined by incorporation of

conclusionsOur data demonstrate for the first time that curcumin prevents fibrotic deposits by modulating collagen turnover, assembly and deposition in BLM-instilled rat lungs, and that curcumin treatment protects against BLM activation of macrophages by suppressing the release of TGF-β1.

Indexed as

AnimalsBleomycinBronchoalveolar Lavage FluidCollagenCurcuminExtracellular MatrixIdiopathic Pulmonary FibrosisLungMacrophages, AlveolarMaleRatsRats, WistarTransforming Growth Factor betaBleomycinCollagenCurcuminTransforming Growth Factor betaBleomycinCollagenCurcuminExtracellular matrixLung fibrosis

Identifiers

PMID34643929
OpenAlexW3207060819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.