Evidence map›Paper›PMID 34643928›Full record

ArticleMolecular biology reports2021

Single-stranded DNA generated by high temperature accepts protons and builds up mutagenic and carcinogenic strong acids.

Yuhan Lin, Xiaoxiao Zhang, Yuchuan Wang, Jiaming Zhang, Qiuyun Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yuhan LinSchool of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.
Xiaoxiao ZhangYunnan Key Laboratory of Stem Cell and Regenerative Medicine, Biomedical Engineering Research Center, Kunming Medical University, Kunming, 650500, China.
Yuchuan WangSchool of Basic Medical Sciences, North China University of Science and Technology, Tangshan, 063210, Hebei, China.
Jiaming ZhangSchool of Chemistry, Sun Yat-sen University, Guangzhou, 510275, China.
Qiuyun LiuSchool of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China. lsslqy@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0001-5533-0128
Sun Yat-sen University · CNKunming Medical University · CNNorth China University of Science and Technology · CN

Funding

Guangzhou Science and Technology Program 201804010328Science and Technology Transformation Program of Sun Yat-sen University of China 33000-18843234
6 · The paper itself

Abstract

Malignancies are caused by genetic or environmental factors. Esophageal carcinoma can be triggered by consumption of hot food and beverages. Here we propose that high temperature is one of the culprits and it leads to DNA denaturation. Subsequently the exposed hydrogen bonding acceptors in single stranded DNA attract protons which enhance the formation of mutagenic and carcinogenic strong acids such as HCl. Faster mutation of single-stranded DNA viruses than that of double-stranded DNA viruses lends support to this theory.

Indexed as

Nucleic Acid DenaturationCarcinogenesisCarcinogensDNA, Single-StrandedEsophageal NeoplasmsHot TemperatureHumansCarcinogensDNA, Single-StrandedDNA denaturationEnvironmental factorsEsophageal carcinomaHigh temperatureHydrogen bonding

Identifiers

PMID34643928
OpenAlexW3206959652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.