Evidence map›Paper›PMID 34643927›Full record

ReviewMolecular biology reports2022

Corticosteroids for COVID-19: worth it or not?

Fariya Akter, Yusha Araf, Mohammad Jakir Hosen

Abstract readReview
In one paragraph

Review in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Secondary pulmonary infection byWorld journal of clinical cases · 2023
    Article
  10. Article
  11. Severe COVID-19: Drugs and Clinical Trials.Journal of clinical medicine · 2023
    Review
  12. Article
  13. Article
  14. Glucocorticoid Therapy in COVID-19.Seminars in respiratory and critical care medicine · 2023
    Review
  15. Drugs for COVID-19: An Update.Molecules (Basel, Switzerland) · 2022
    Review
  16. Glucocorticoids and COVID-19.Pharmacological research · 2022
    Review
  17. Management of hyperinflammation in COVID-19 patients.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022
    Review
  18. Article
  19. Corticosteroid Therapy in COVID-19 Associated With In-hospital Mortality in Geriatric Patients: A Propensity Matched Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fariya AkterBiotechnology Program, Department of Mathematics and Natural Sciences, Brac University, Dhaka, Bangladesh.
Yusha ArafDepartment of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh.ORCID http://orcid.org/0000-0002-0144-5875
Mohammad Jakir HosenDepartment of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh. jakir-gen@sust.edu.ORCID http://orcid.org/0000-0001-6444-0214

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced COVID-19 implied the presence of excessive proinflammatory cytokines and chemokines in patients causing significant morbidity and mortality. To diminish systemic hyper inflammation, a few physicians and researchers have utilized corticosteroids. Corticosteroid implementation has increased after the publication of interim guidelines regarding corticosteroid use in COVID-19 patients by WHO, despite the remaining controversies regarding long-term side effects and disease progression capability of corticosteroids. In different studies, the implementation of corticosteroids on COVID-19 patients revealed controversial results, which require further intensive research. This review will present the current outcomes and possibilities of using corticosteroids to treat COVID-19 patients.

Indexed as

Adrenal Cortex HormonesCOVID-19 Drug TreatmentChemokinesCytokine Release SyndromeCytokinesHumansImmunosuppressive AgentsInflammationSARS-CoV-2Adrenal Cortex HormonesChemokinesCytokinesImmunosuppressive AgentsCorticosteroidsCOVID-19Cytokine stormImmunosuppressionInflammatory-moleculesSide-effects

Identifiers

PMID34643927
PMCPMC8511618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.