Evidence map›Paper›PMID 34643827›Full record

ArticleAIDS and behavior2022

PrEP Use and Adherence Among Transgender Patients.

Jae Downing, Kimberly Yee, Jae M Sevelius

Open access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  12. Trajectories of Pre-exposure Prophylaxis Adherence Among Commercially Insured Individuals.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jae DowningDepartment of Health Policy and Management, OHSU-PSU School of Public Health, Portland, OR, USA.
Kimberly YeeDepartment of Health Policy and Management, OHSU-PSU School of Public Health, Portland, OR, USA. kimyee@pdx.edu.ORCID http://orcid.org/0000-0002-1686-8627
Jae M SeveliusDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Oregon Health & Science University · USUniversity of California, San Francisco · US

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sheri Ann Lippman · 2001 to 2026
$57.4M
Scholars in Women's Health Research Across the LifespanK12HD043488 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MYATT, LESLIE · 2002 to 2023
$10.4M
Evaluating health disparities among likely transgender persons in OregonR01MD011212 · NIMHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MCCONNELL, KENNETH JOHN · 2016 to 2019
$2.5M
Mentoring clinical investigators in patient-oriented research on substance use and HIVK24DA051328 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEVELIUS, JAE M. · 2020 to 2024
$771k
Eunice Kennedy Shriver National Institute of Child Health and Human Development K12HD043488NICHD NIH HHS K12 HD043488NIDA NIH HHS K24 DA051328NIDA NIH HHS K24DA051328NIMHD NIH HHS 3R01MD011212-0S31NIMHD NIH HHS R01 MD011212NIMH NIH HHS P30 MH062246
6 · The paper itself

Abstract

This cross-sectional study used 2012 to 2019 Oregon Medicaid claims to estimate the prevalence of PrEP use and identify determinants of high adherence across transgender and cisgender men and women. Gender identity (cisgender woman/man; transgender, assigned female sex at birth [AFAB]; transgender, assigned male sex at birth [AMAB]) was based on medical history and enrollment records. Proportion of days covered ≥ 0.80 was considered high adherence to PrEP. The association between gender identity and PrEP uptake or high adherence was estimated using multivariable logistic regression. 1555 PrEP users, including 171 (11.0%) cis women, 1171 (75.3%) cis men, 67 (4.3%) AFAB, and 146 (9.4%) AMAB individuals, were included. The probability of PrEP use per 10,000 people was highest in transgender groups (AMAB 546.8, 95% CI 462.4-631.3; AFAB 226.5, 95% CI 173.4-279.6), followed by cisgender men (20.6, 95% CI 19.4, 21.8) and women (2.6, 95% CI 2.2, 3.0). High adherence was significantly lower in AMAB recipients (72.6%) than cisgender women (86.0%) and cisgender men (82.2%). Among the 279 PrEP users with female on their enrollment record, 76 (27.2%) were AMAB, while among the 1276 PrEP users with male on their enrollment record, 35 (2.7%) were AFAB. This demonstrates the importance of surveillance methods that take gender identity into account in addition to sex assigned at birth. There were significant differences in PrEP use and adherence by gender identity. PrEP surveillance, outreach, and prescribing practices must consider gender identity-unique risk factors.

Indexed as

HIV InfectionsPre-Exposure ProphylaxisTransgender PersonsTranssexualismAdolescentAdultCross-Sectional StudiesFemaleGender IdentityHomosexuality, MaleHumansMaleMiddle AgedYoung AdultAdherenceDifferential misclassificationMedicaidPre-exposure prophylaxis (PrEP)Transgender

Identifiers

PMID34643827
PMCPMC9351441
OpenAlexW3205497577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.