Evidence map›Paper›PMID 34643797›Full record

Observational studyInternational orthopaedics2021

Risk of post-operative cardiovascular event in elderly patients with pre-existing cardiovascular disease who are undergoing hip fracture surgery.

Yan Luo, Yu Jiang, Hongli Xu, Houchen Lyu, Licheng Zhang, Pengbin Yin, Peifu Tang

Registry-linked trialOpen access · hybridAbstract readObservational Study
In one paragraph

Observational study in International orthopaedics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07709377 (Artificial Intelligence-Based Analysis of Risk Factors and Risk Prediction Model for Major Adverse Cardiovascular Events Following Hip Fracture Surgery in the Elderly), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07709377 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Artificial Intelligence-Based Analysis of Risk Factors and Risk Prediction Model for Major Adverse Cardiovascular Events Following Hip Fracture Surgery in the Elderly

Typeobservational_patient_registrySponsorBeijing Anzhen HospitalRan2025 to 2028Enrolled600ConditionsHip Fracture, MACE, Elderly, Perioperative Complications
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yan Luo *Department of Orthopaedics, Chinese PLA General Hospital, Beijing, China.
Yu Jiang *Department of Orthopaedics, Chinese PLA General Hospital, Beijing, China.
Hongli XuMedical Big Data Research Centre, Chinese PLA General Hospital, Beijing, China.
Houchen LyuDepartment of Orthopaedics, Chinese PLA General Hospital, Beijing, China.
Licheng ZhangDepartment of Orthopaedics, Chinese PLA General Hospital, Beijing, China.
Pengbin YinDepartment of Orthopaedics, Chinese PLA General Hospital, Beijing, China. yinpengbin@gmail.com.ORCID http://orcid.org/0000-0002-5391-4477
Peifu TangDepartment of Orthopaedics, Chinese PLA General Hospital, Beijing, China.
Chinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the association between pre-existing cardiovascular disease (CVD) and the risk of developing post-operative cardiovascular event among elderly patients who underwent hip fracture surgery.

methodsWe performed an observational study among patients with acute hip fracture aged at least 65 years and who received surgical intervention. Hip fracture patients with pre-existing CVD were matched for age, gender, fracture type, and year of admission with patients without pre-existing CVD. The primary endpoint was post-operative cardiovascular events, and patients were followed until discharge from hospital. Conditional logistic regression was used to determine the association between pre-existing CVD and post-operative cardiovascular event after adjusting for potential confounders including age, body mass index, time from fracture to surgery, pre-existing comorbidities, and the Charlson Comorbidity Index (CCI).

resultsThe study matched 858 pairs of patients with and without pre-existing CVD. Post-operative cardiovascular events developed in 40 and 14 patients with and without pre-existing CVD (44.6 versus 16.3 per 1000 persons), respectively. Compared to patients without pre-existing CVD, patients with any pre-existing CVD were more likely to develop post-operative cardiovascular events, with a crude odds ratio (OR) of 2.857 [95% confidence interval (CI), 1.554 to 5.251] and multivariable adjusted OR of 2.850 (95% CI, 1.318 to 7.139), respectively.

conclusionIn elderly patients who received hip fracture surgery, patients with pre-existing CVD are at a higher risk of developing post-operative cardiovascular events. Appropriate screening for this vulnerable population is recommended to prevent the risk of post-operative complications.

Indexed as

Cardiovascular DiseasesHip FracturesAgedComorbidityFracture FixationHumansPostoperative PeriodRisk FactorsElderlyHip fracturePost-operative cardiovascular eventsPre-existing cardiovascular disease

Identifiers

PMID34643797
PMCPMC8626362
OpenAlexW3206178729

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.