ArticleThe Journal of nutrition2022
Assessment of Dietary Choline Intake, Contributing Food Items, and Associations with One-Carbon and Lipid Metabolites in Middle-Aged and Elderly Adults: The Hordaland Health Study.
Article in The Journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Changes in Choline Metabolites and Ceramides in Response to a DASH-Style Diet in Older Adults.Nutrients · 2023Trial
- Comprehensive safety assessment of novel dicholine folate vitamin.Toxicology reports · 2026Article
- Development of a Choline Database for Thai Food and a Population-Wide Assessment of Choline Intake in Thailand.Nutrients · 2026Article
- Nutritional and bioactive properties of native chicken eggs: Global perspectives on human health implications.Poultry science · 2026Review
- Dietary intake and food sources of choline in Koreans: findings from Korea National Health and Nutrition Examination survey 2018-2022.Nutrition research and practice · 2026Article
- 1H MR Spectroscopy at 3T for Hepatic Choline Quantification in Healthy Young Women: A Translational Imaging Study with Dietary Correlation.Current medical imaging · 2026Article
- Analyzing dietary exposure to critical nutrients on a plant-based diet using the food- and total nutrient index.Nutrition journal · 2025Article
- Associations of first-trimester TMAO and its precursors with gestational diabetes mellitus: a pilot prospective cohort study.Frontiers in nutrition · 2025Article
- Association between dietary choline intake and odds of preeclampsia: a case-control study.Frontiers in nutrition · 2025Article
- Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study.Diabetes care · 2024Article
- Dietary choline intake in European and non-european populations: current status and future trends-a narrative review.Nutrition journal · 2024Review
- Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris.The British journal of nutrition · 2024Article
- Comprehensive transcriptomics and metabolomics analyses reveal that hyperhomocysteinemia is a high risk factor for coronary artery disease in a chinese obese population aged 40-65: a prospective cross-sectional study.Cardiovascular diabetology · 2023Article
- Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults.BMC endocrine disorders · 2023Article
- Uncontrolled Thyroid during Pregnancy Alters the Circulative and Exerted Metabolome.International journal of molecular sciences · 2022Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCholine is an essential nutrient for humans and is involved in various physiologic functions. Through its metabolite betaine, it is closely connected to the one-carbon metabolism, and the fat-soluble choline form phosphatidylcholine is essential for VLDL synthesis and secretion in the liver connecting choline to the lipid metabolism. Dietary recommendations for choline are not available in the Nordic countries primarily due to data scarcity.
objectivesThe aim of this study was to investigate the dietary intake of total choline and individual choline forms, dietary sources, and the association of total choline intake with circulating one-carbon metabolites and lipids.
methodsWe included 5746 participants in the Hordaland Health Study, a survey including community-dwelling adults born in 1925-1927 (mean age 72 y, 55% women) and 1950-1951 (mean age 48 y, 57% women). Dietary data were obtained using a 169-item FFQ, and choline content was calculated using the USDA Database for Choline Content of Common Foods, release 2. Metabolites of the one-carbon and lipid metabolism were measured in a nonfasting blood sample obtained at baseline, and the association with total choline intake was assessed using polynomial splines.
resultsThe geometric mean (95% prediction interval) energy-adjusted total choline intake was 260 (170, 389) mg/d, with phosphatidylcholine being the main form (44%). The major food items providing dietary choline were eggs, low-fat milk, potatoes, and leafy vegetables. Dietary total choline was inversely associated with circulating concentrations of total homocysteine, glycine, and serine and positively associated with choline, methionine, cystathionine, cysteine, trimethyllysine, trimethylamine-N-oxide, and dimethylglycine. A weak association was observed between choline intake and serum lipids.
conclusionsPhosphatidylcholine was the most consumed choline form in community-dwelling adults in Norway. Our findings suggest that choline intake is associated with the concentration of most metabolites involved in the one-carbon and lipid metabolism.
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