Observational studyJournal of the American Medical Informatics Association : JAMIA2022
Gender-specific clinical risk scores incorporating blood pressure variability for predicting incident dementia.
Observational study in Journal of the American Medical Informatics Association : JAMIA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- PowerAI-Diabetes: Review of glycemic and lipid variability to predict cardiovascular events in Chinese diabetic population.npj metabolic health and disease · 2024Review
- Artificial Intelligence in Hypertension Management: An Ace up Your Sleeve.Journal of cardiovascular development and disease · 2023Review
- The Impact of Cardiac Comorbidity Sequence at Baseline and Mortality Risk in Type 2 Diabetes Mellitus: A Retrospective Population-Based Cohort Study.Life (Basel, Switzerland) · 2022Article
- Gender-specific clinical risk scores incorporating blood pressure variability for predicting incident dementia.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- Letter to the editors in response to "Gender-specific clinical risk scores incorporating blood pressure variability for predicting incident dementia".Journal of the American Medical Informatics Association : JAMIA · 2022Article
- Extracellular to Intracellular Body Water and Cognitive Function among Healthy Older and Younger Adults.Journal of functional morphology and kinesiology · 2022Article
- Informatics for sex- and gender-related health: understanding the problems, developing new methods, and designing new solutions.Journal of the American Medical Informatics Association : JAMIA · 2022Article
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12 authors.
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Abstract
introductionThe present study examined the gender-specific prognostic value of blood pressure (BP) and its variability in the prediction of dementia risk and developed a score system for risk stratification. MATERIALS AND
methodsThis was a retrospective, observational population-based cohort study of patients admitted to government-funded family medicine clinics in Hong Kong between January 1, 2000 and March 31, 2002 with at least 3 blood pressure measurements. Gender-specific risk scores for dementia were developed and tested.
resultsThe study consisted of 74 855 patients, of whom 3550 patients (incidence rate: 4.74%) developed dementia over a median follow-up of 112 months (IQR= [59.8-168]). Nonlinear associations between diastolic/systolic BP measurements and the time to dementia presentation were identified. Gender-specific dichotomized clinical scores were developed for males (age, hypertension, diastolic and systolic BP and their measures of variability) and females (age, prior cardiovascular, respiratory, gastrointestinal diseases, diabetes mellitus, hypertension, stroke, mean corpuscular volume, monocyte, neutrophil, urea, creatinine, diastolic and systolic BP and their measures of variability). They showed high predictive strengths for both male (hazard ratio [HR]: 12.83, 95% confidence interval [CI]: 11.15-14.33, P value < .0001) and female patients (HR: 26.56, 95% CI: 14.44-32.86, P value < .0001). The constructed gender-specific scores outperformed the simplified systems without considering BP variability (C-statistic: 0.91 vs 0.82), demonstrating the importance of BP variability in dementia development.
conclusionGender-specific clinical risk scores incorporating BP variability can accurately predict incident dementia and can be applied clinically for early disease detection and optimized patient management.
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