Evidence map›Paper›PMID 34643672›Full record

SynthesisEuropean heart journal. Quality of care & clinical outcomes2022

Effect of coronary artery bypass grafting on quality of life: a meta-analysis of randomized trials.

Ruth Masterson Creber, Arnaldo Dimagli, Cristiano Spadaccio, Annie Myers, Marco Moscarelli, Michelle Demetres, Matthew Little, Stephen Fremes, Mario Gaudino

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in European heart journal. Quality of care & clinical outcomes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Minimal clinically important differences in patient-reported outcomes after coronary artery bypass surgery in the arterial revascularization trial.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024
    Trial
  2. Review
  3. Article
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  9. Coronary artery surgery outcome differences by sex.Indian journal of thoracic and cardiovascular surgery · 2026
    Review
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  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Early home discharge after robot-assisted coronary artery bypass grafting.Interactive cardiovascular and thoracic surgery · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ruth Masterson CreberDivision of Health Informatics, Department of Healthcare Policy and Research, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-4238-9902
Arnaldo DimagliBristol Heart Institute, University of Bristol, Bristol, UK.ORCID 0000-0003-0055-8656
Cristiano SpadaccioInstitute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
Annie MyersDivision of Health Informatics, Department of Healthcare Policy and Research, Weill Cornell Medicine, New York, NY, USA.
Marco MoscarelliDepartment of Cardiac Surgery, Imperial College London, London, UK.ORCID 0000-0002-8373-8486
Michelle DemetresSamuel J. Wood Library and C.V. Starr Biomedical Information Center, Weill Cornell Medicine, New York, NY USA.ORCID 0000-0002-4997-7707
Matthew LittleHealth Economics Research Centre, Nuffield Department of Population Health, University of Oxford, UK.
Stephen FremesSunnybrook Health Sciences Center, University of Toronto, Toronto, Canada.
Mario GaudinoDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-4680-0815

Funding

Strengthening Healthcare and Research Engagement through Data Sharing: SHARER01NS123639 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Mario FL Gaudino, Ruth Marie Masterson Creber · 2021 to 2026
$4.4M
Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: Quality of Life (ROMA:QOL)R01HL152021 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GAUDINO, MARIO FL, MASTERSON CREBER, RUTH MARIE · 2020 to 2024
$4.1M
Improve the Meaning of Patient Reported Outcomes to Evaluate Effectiveness for Cardiac Care" (IMPROVE-Cardiac Care)R01HL161458 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MASTERSON CREBER, RUTH MARIE · 2022 to 2025
$2.6M
Should we return patient reported outcomes to human subjects participants?-exploring ethical obligationsR00NR016275 · NINR · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASTERSON CREBER, RUTH MARIE · 2018 to 2020
$896k
NHLBI NIH HHS R01 HL152021NHLBI NIH HHS R01 HL161458NINDS NIH HHS R01 NS123639NINR NIH HHS R00 NR016275
6 · The paper itself

Abstract

aimsWe conducted a systematic review and meta-analysis to evaluate temporal trends in quality of life (QoL) after coronary artery bypass grafting (CABG) surgery in randomized clinical trials, and a quantitative comparison from before surgery to up to 5 years after surgery. METHODS AND

resultsWe searched MEDLINE, CINAHL, EMBASE, Cochrane Library, and PsycINFO from 2010 to 2020 to identify studies that included the measurement of QoL in patients undergoing CABG. The primary outcome was the Seattle Angina Questionnaire (SAQ), and secondary outcomes were the 36-item Short Form Health Survey (SF-36) and EuroQol Questionnaire (EQ-5D). We pooled the means and the weighted mean differences over the follow-up period. In the meta-analysis, 2586 studies were screened and 18 full-text studies were included. There was a significant trend towards higher QoL scores from before surgery to 1 year post-operatively for the SAQ angina frequency (AF), SAQ QoL, SF-36 physical component (PC), and EQ-5D, whereas the SF-36 mental component (MC) did not improve significantly. The weighted mean differences from before surgery to 1 year after was 24 [95% confidence interval (CI): 21.6-26.4] for the SAQ AF, 31 (95% CI: 27.5-34.6) for the SAQ QoL, 9.8 (95% CI: 7.1-12.8) for the SF-36 PC, 7.1 (95% CI: 4.2-10.0) for the SF-36 MC, and 0.1 (95% CI: 0.06-0.14) for the EQ-5D. There was no evidence of publication bias or small-study effect.

conclusionCABG had both short- and long-term improvements in disease-specific QoL and generic QoL, with the largest improvement in angina frequency.

Indexed as

Coronary Artery BypassQuality of LifeAngina PectorisHumansRandomized Controlled Trials as TopicSurveys and QuestionnairesCABGCoronary artery diseaseQuality of life

Identifiers

PMID34643672
PMCPMC9071531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.