Evidence map›Paper›PMID 34643658›Full record

ArticleJournal of vision2021

The retinal and perceived locus of fixation in the human visual system.

Markku Kilpeläinen, Nicole M Putnam, Kavitha Ratnam, Austin Roorda

Open access · goldAbstract read
In one paragraph

Article in Journal of vision, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  7. Spatial and Temporal Factors Influencing Fixational Saccades.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Asymmetries in Foveal Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  9. In Vivo Cone Photoreceptor Topography of the Human Foveola.Investigative ophthalmology & visual science · 2025
    Article
  10. The Optimal Retinal Locus for High-Resolution Vision in Space and Time.bioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Asymmetries in foveal vision.bioRxiv : the preprint server for biology · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Binocularity Principles of PRL Development in Patients With Macular Disease.Investigative ophthalmology & visual science · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Markku KilpeläinenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Nicole M PutnamArizona College of Optometry, Midwestern University, Glendale, AZ, USA.
Kavitha RatnamFacebook Reality Labs, Redmond, WA, USA.
Austin RoordaHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, Berkeley, CA, USA.
Meta (United States) · USMidwestern University · USUniversity of California, Berkeley · USUniversity of Helsinki · FI

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8M
TRAINING PROGRAM IN VISION SCIENCET32EY007043 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Suzanne MJ FLEISZIG · 1985 to 2026
$12.9M
Advanced Technology to Study Visual Function on a Cellular ScaleR01EY023591 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI DUNCAN, JACQUE LYNNE, ROORDA, AUSTIN · 2014 to 2023
$11.2M
NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY023591NEI NIH HHS T32 EY007043
6 · The paper itself

Abstract

Due to the dramatic difference in spatial resolution between the central fovea and the surrounding retinal regions, accurate fixation on important objects is critical for humans. It is known that the preferred retinal location (PRL) for fixation of healthy human observers rarely coincides with the retinal location with the highest cone density. It is not currently known, however, whether the PRL is consistent within an observer or is subject to fluctuations and, moreover, whether observers' subjective fixation location coincides with the PRL. We studied whether the PRL changes between days. We used an adaptive optics scanning laser ophthalmoscope to project a Maltese cross fixation target on an observer's retina and continuously imaged the exact retinal location of the target. We found that observers consistently use the same PRL across days, regardless of how much the PRL is displaced from the cone density peak location. We then showed observers small stimuli near the visual field location on which they fixated, and the observers judged whether or not the stimuli appeared in fixation. Observers' precision in this task approached that of fixation itself. Observers based their judgment on both the visual scene coordinates and the retinal location of the stimuli. We conclude that the PRL in a normally functioning visual system is fixed, and observers use it as a reference point in judging stimulus locations.

Indexed as

Fixation, OcularRetinaFovea CentralisHumansOphthalmoscopesScotomaVisual Fields

Identifiers

PMID34643658
PMCPMC8525830
OpenAlexW3206177709

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.