Evidence map›Paper›PMID 34643620›Full record

ArticleJournal of the Chinese Medical Association : JCMA2021

Evaluating the biocompatibility and biological performance of FePt-decorated nano-epoxy nanoparticles in mesenchymal stem cells.

Ruey-Hwang Chou, Meng-Yin Yang, Yi-Ping Yang, Chun-An Yeh, Wei-Yi Lai, Tzu-Wei Lin, Yuan-Chi Teng, Shu-Chen Hsieh, Mei-Lang Kung, Hsien-Hsu Hsieh and 1 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Chinese Medical Association : JCMA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Ruey-Hwang ChouGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, ROC.
Meng-Yin YangNeurological Institute Head of Department of Neurosurgery Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Yi-Ping YangDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Chun-An YehGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, ROC.
Wei-Yi LaiDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Tzu-Wei LinDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Yuan-Chi TengDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Shu-Chen HsiehDepartment of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC.
Mei-Lang KungDepartment of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC.
Hsien-Hsu HsiehBlood Bank, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Huey-Shan HungGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, ROC.
Taipei Veterans General Hospital · TWChina Medical University · TWCentral Taiwan University of Science and Technology · TWKaohsiung Veterans General Hospital · TWNational Sun Yat-sen University · TWTaichung Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNanoparticles have wide potential applications in biolabeling, bioimaging, and cell tracking. Development of dual functional nanoparticles increases the versatility.

methodsWe combined the fluorescent property of nano-epoxy (N-Epo) and the magnetic characteristic of FePt to fabricate the FePt-decorated N-Epo (N-Epo-FePt). The size in diameter of N-Epo-FePt (177.38 ± 39.25 nm) was bigger than N-Epo (2.28 ± 1.01 nm), both could be absorbed into mesenchymal stem cells (MSCs) via clathrin-mediated endocytosis and have multiple fluorescent properties (blue, green, and red).

resultsN-Epo-FePt prevented N-Epo-induced platelet activation, CD68+-macrophage differentiation in blood, and intracellular ROS generation in MSCs. The induction of apoptosis and the inhibitory effects of N-Epo-FePt on cell migration, MMP-9 activity, and secretion of SDF-1α were less than that of N-Epo in MSCs.

conclusionN-Epo-FePt was more biocompatible without altering biological performance than N-Epo in MSCs. These results suggest that N-Epo-FePt nanoparticle can be used for fluorescence labeling of MSCs and is potential to apply to bioimaging and cell tracking of MSCs in vivo by magnetic resonance imaging or computed tomography.

Indexed as

Materials TestingMesenchymal Stem CellsNanoparticlesCell Line, TumorHumansMicroscopy, FluorescenceTomography, X-Ray Computed

Identifiers

PMID34643620
PMCPMC12966179
OpenAlexW3206771119

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.