Evidence map›Paper›PMID 34643436›Full record

ArticleJournal of virology2022

Powassan Viruses Spread Cell to Cell during Direct Isolation from

Jonas N Conde, Santiago Sanchez-Vicente, Nicholas Saladino, Elena E Gorbunova, William R Schutt, Megan C Mladinich, Grace E Himmler, Jorge Benach, Hwan Keun Kim, Erich R Mackow

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Tick-induced neurological disorders.Journal of neurology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Powassan Virus Encephalitis.Infectious disease clinics of North America · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jonas N CondeDepartment of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.ORCID 0000-0001-5895-1114
Santiago Sanchez-VicenteCenter for Infection and Immunity, Mailman School of Public Health, Columbia University New York, New York, USA.
Nicholas SaladinoDepartment of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Elena E GorbunovaDepartment of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
William R SchuttDepartment of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Megan C MladinichDepartment of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Grace E HimmlerDepartment of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Jorge BenachDepartment of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Hwan Keun KimDepartment of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Erich R MackowDepartment of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.ORCID 0000-0001-9156-1222
Stony Brook University · USColumbia University · US

Funding

Antigen Specific Response to BorreliaR01AI027044 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI BENACH, JORGE L. · 1989 to 2020
$3.7M
MOLECULAR AND CELL BIOLOGY OF INFECTIOUS DISEASEST32AI007539 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KONOPKA, JAMES B · 1998 to 2023
$3.6M
NIAID NIH HHS R01 AI027044NIAID NIH HHS T32 AI007539
6 · The paper itself

Abstract

Powassan viruses (POWVs) are neurovirulent tick-borne flaviviruses emerging in the northeastern United States, with a 2% prevalence in Long Island (LI) deer ticks (Ixodes scapularis). POWVs are transmitted within as little as 15 min of a tick bite and enter the central nervous system (CNS) to cause encephalitis (10% of cases are fatal) and long-term neuronal damage. POWV-LI9 and POWV-LI41 present in LI

Indexed as

Disease VectorsAnimalsCells, CulturedEncephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneEndothelial CellsGene OrderGenome, ViralHost-Pathogen InteractionsHumansInterferonsIxodesPericytesPhylogenyVirus ReplicationInterferonsbasolateralblood-brain barriercell-to-cell spreadendothelial cellsflaviviruspericytesPowassan virustick inoculation

Identifiers

PMID34643436
PMCPMC8754205
OpenAlexW3206867623

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.