Evidence map›Paper›PMID 34643433›Full record

ArticleJournal of virology2022

Role of African Swine Fever Virus Proteins EP153R and EP402R in Reducing Viral Persistence in Blood and Virulence in Pigs Infected with BeninΔDP148R.

Vlad Petrovan, Anusyah Rathakrishnan, Muneeb Islam, Lynnette C Goatley, Katy Moffat, Pedro J Sanchez-Cordon, Ana L Reis, Linda K Dixon

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Vlad Petrovan *The Pirbright Institute, Pirbright, Woking, Surrey, UK.
Anusyah Rathakrishnan *The Pirbright Institute, Pirbright, Woking, Surrey, UK.
Muneeb IslamThe Pirbright Institute, Pirbright, Woking, Surrey, UK.
Lynnette C GoatleyThe Pirbright Institute, Pirbright, Woking, Surrey, UK.
Katy MoffatThe Pirbright Institute, Pirbright, Woking, Surrey, UK.
Pedro J Sanchez-CordonThe Pirbright Institute, Pirbright, Woking, Surrey, UK.
Ana L ReisThe Pirbright Institute, Pirbright, Woking, Surrey, UK.
Linda K DixonThe Pirbright Institute, Pirbright, Woking, Surrey, UK.ORCID 0000-0003-3845-3016
The Pirbright Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/I/00007031Biotechnology and Biological Sciences Research Council BBS/E/I/00007034Biotechnology and Biological Sciences Research Council BBS/E/I/00007037Biotechnology and Biological Sciences Research Council BBS/E/I/00007039
6 · The paper itself

Abstract

The limited knowledge on the role of many of the approximately 170 proteins encoded by African swine fever virus restricts progress toward vaccine development. Previously, the DP148R gene was deleted from the genome of genotype I virulent Benin 97/1 isolate. This virus, BeninΔDP148R, induced transient moderate clinical signs after immunization and high levels of protection against challenge. However, the BeninΔDP148R virus and genome persisted in blood over a prolonged period. In the current study, deletion of either EP402R or EP153R genes individually or in combination from BeninΔDP148R genome was shown not to reduce virus replication in macrophages

Indexed as

African Swine FeverAfrican Swine Fever VirusAnimalsAntibodies, ViralAntigens, ViralBiomarkersCells, CulturedGenetic EngineeringGenotypeHost-Pathogen InteractionsImmunizationMacrophagesSequence DeletionSwineViral ProteinsViral VaccinesAntibodies, ViralAntigens, ViralBiomarkersViral ProteinsViral VaccinesAfrican swine fever virusEP153REP402Rmacrophagespersistencevirulence determinants

Identifiers

PMID34643433
PMCPMC8754224
OpenAlexW3207730782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.