Evidence map›Paper›PMID 34643428›Full record

ArticleJournal of virology2022

Perturbing HIV-1 Ribosomal Frameshifting Frequency Reveals a

Bayleigh E Benner, James W Bruce, Jacob R Kentala, Magdalena Murray, Jordan T Becker, Pablo Garcia-Miranda, Paul Ahlquist, Samuel E Butcher, Nathan M Sherer

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bayleigh E BennerDepartment of Oncology (McArdle Laboratory for Cancer Research), Institute for Molecular Virology, and Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-6266-5740
James W BruceDepartment of Oncology (McArdle Laboratory for Cancer Research), Institute for Molecular Virology, and Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jacob R KentalaDepartment of Oncology (McArdle Laboratory for Cancer Research), Institute for Molecular Virology, and Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Magdalena MurrayDepartment of Oncology (McArdle Laboratory for Cancer Research), Institute for Molecular Virology, and Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jordan T BeckerDepartment of Oncology (McArdle Laboratory for Cancer Research), Institute for Molecular Virology, and Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-0239-5443
Pablo Garcia-MirandaDepartment of Oncology (McArdle Laboratory for Cancer Research), Institute for Molecular Virology, and Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Paul AhlquistDepartment of Oncology (McArdle Laboratory for Cancer Research), Institute for Molecular Virology, and Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Samuel E ButcherDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Nathan M ShererDepartment of Oncology (McArdle Laboratory for Cancer Research), Institute for Molecular Virology, and Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-9974-236X
University of Wisconsin–Madison · US

Funding

Visualizing EBV and HCMV DNA Dynamics During InfectionP01CA022443 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI WILLIAM M. SUGDEN · 1985 to 2026
$53.1M
BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
Biophysical investigations of RNA complexes essential for gene expressionR35GM118131 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Samuel E Butcher · 2016 to 2026
$5.1M
The Cell Biology of HIV-1 Genome TraffickingR01AI110221 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Nathan M Sherer · 2014 to 2026
$4.4M
Inhibitor of FtsZ Polymerization in M. tuberculosisR01AI050470 · NIAID · SOUTHERN RESEARCH INSTITUTE · PI REYNOLDS, ROBERT C · 2002 to 2004
$1.7M
NCI NIH HHS P01 CA022443NIAID NIH HHS R01 AI050470NIAID NIH HHS R01 AI110221NIGMS NIH HHS R35 GM118131NIGMS NIH HHS T32 GM008349
6 · The paper itself

Abstract

HIV-1 virion production is driven by Gag and Gag-Pol (GP) proteins, with Gag forming the bulk of the capsid and driving budding, while GP binds Gag to deliver the essential virion enzymes protease, reverse transcriptase, and integrase. Virion GP levels are traditionally thought to reflect the relative abundances of GP and Gag in cells (∼1:20), dictated by the frequency of a -1 programmed ribosomal frameshifting (PRF) event occurring in

Indexed as

Frameshifting, RibosomalGene Expression Regulation, ViralVirus Assemblygag Gene Products, Human Immunodeficiency VirusHIV-1HIV InfectionsHIV Protease InhibitorsHumansInverted Repeat SequencesModels, BiologicalNucleic Acid ConformationRNA StabilityRNA, ViralVirionVirus Replicationgag Gene Products, Human Immunodeficiency VirusHIV Protease InhibitorsRNA, Viralcis-acting RNA elementGagGag-PolHIVPRFproteasereverse transcriptionribosomal frameshiftvirionvirus assembly

Identifiers

PMID34643428
PMCPMC8754204
OpenAlexW3205716774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.