Evidence map›Paper›PMID 34643425›Full record

ArticlemSphere2021

CRISPR-Mediated Transcriptional Repression in Toxoplasma gondii.

Benedikt M Markus, Elizabeth A Boydston, Sebastian Lourido

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Benedikt M MarkusWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.ORCID 0000-0002-6823-9072
Elizabeth A BoydstonWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.ORCID 0000-0001-8365-0436
Sebastian LouridoWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.ORCID 0000-0002-5237-1095
Whitehead Institute for Biomedical Research · USUniversity of Freiburg · DE

Funding

Control of parasite invasion by a microneme protein complex conserved in ApicomplexansR01AI144369 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LOURIDO, SEBASTIAN · 2020 to 2024
$2.4M
NIAID NIH HHS R01 AI144369
6 · The paper itself

Abstract

Tools for tuning endogenous gene expression are key to determining the genetic basis of diverse cellular phenotypes. Although synthetic regulatable promoters are available in

Indexed as

CRISPR-Cas SystemsCRISPR-Associated Protein 9Gene EditingGene ExpressionGene Knockout TechniquesRNA, Guide, CRISPR-Cas SystemsToxoplasmaCRISPR-Associated Protein 9RNA, Guide, CRISPR-Cas SystemsApicomplexaCRISPRiCRISPR interferencedCas9genome engineeringknockdownparasite

Identifiers

PMID34643425
PMCPMC8513686
OpenAlexW3206385295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.