ArticlemSphere2021
Why Is the Biodegradation of Polyfluorinated Compounds So Rare?
Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Enriching microbes capable of fluorotelomer acid defluorination: thermodynamic constraints and experimental challenges.NPJ emerging contaminants · 2026Article
- Emerging contaminants of perfluoroalkyl carboxylic acids (PFCAs): a review of sources, occurrence, and accumulation in plants.Environmental geochemistry and health · 2025Review
- Perfluoroalkane Sulfonamides and Derivatives, a Different Class of PFAS: Sorption and Microbial Biotransformation Insights.Environmental science & technology · 2025Review
- Probable New Species of Bacteria of the GenusToxics · 2024Article
- Burning question: Rethinking organohalide degradation strategy for bioremediation applications.Microbial biotechnology · 2024Review
- Synergistic material-microbe interface toward deeper anaerobic defluorination.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Electron bifurcation and fluoride efflux systems implicated in defluorination of perfluorinated unsaturated carboxylic acids byScience advances · 2024Article
- Elucidating the Role of OACS environmental Au · 2024Article
- 'Small volume-big problem': culturing Yarrowia lipolytica in high-throughput micro-formats.Microbial cell factories · 2024Review
- Defluorination of monofluorinated alkane by Rhodococcus sp. NJF-7 isolated from soil.AMB Express · 2024Article
- Toward the development of a molecular toolkit for the microbial remediation of per-and polyfluoroalkyl substances.Applied and environmental microbiology · 2024Review
- RecombinantmBio · 2024Article
- Biodegradation Potential of CToxics · 2023Article
- Influence of PFDA on the nutrient removal from wastewater by hydrogels containing microalgae-bacteria.Heliyon · 2023Article
- Contrasting Mechanisms of Aromatic and Aryl-Methyl Substituent Hydroxylation by the Rieske Monooxygenase Salicylate 5-Hydroxylase.Biochemistry · 2023Article
- Fluoro-recognition: New in vivo fluorescent assay for toluene dioxygenase probing induction by and metabolism of polyfluorinated compounds.Environmental microbiology · 2022Article
- Toward a molecular understanding of fluoride stress in a model Pseudomonas strain.Environmental microbiology · 2022Article
- Role of the CrcB transporter of Pseudomonas putida in the multi-level stress response elicited by mineral fluoride.Environmental microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thousands of heavily fluorinated chemicals are found in the environment, impact human and ecosystem health, and are relatively resistant to biological and chemical degradation. Their persistence in the environment is due to the inability of most microorganisms to biodegrade them. Only a very few examples of polyfluorinated compound biodegradation are known, and the reported rates are very low. This has been mostly attributed to the low chemical reactivity of the C-F bond. This Perspective goes beyond that explanation to highlight microbiological reasons why polyfluorinated compounds resist metabolism. The evolutionary and physiological impediments must be appreciated to better find, study, and harness microbes that degrade polyfluorinated compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.