Evidence map›Paper›PMID 34643404›Full record

ArticleThe journal of physical chemistry. B2021

Tau Protein Binding Modes in Alzheimer's Disease for Cationic Luminescent Ligands.

Yogesh Todarwal, Camilla Gustafsson, Nghia Nguyen Thi Minh, Ingrid Ertzgaard, Therése Klingstedt, Bernardino Ghetti, Ruben Vidal, Carolin König, Mikael Lindgren, K Peter R Nilsson and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Yogesh TodarwalDepartment of Theoretical Chemistry and Biology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, SE-106 91 Stockholm, Sweden.
Camilla GustafssonDepartment of Theoretical Chemistry and Biology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, SE-106 91 Stockholm, Sweden.ORCID 0000-0002-7624-4867
Nghia Nguyen Thi MinhLeibniz University Hannover, Institute of Physical Chemistry and Electrochemistry, Callinstr. 3A, 30167 Hannover, Germany.
Ingrid ErtzgaardDepartment of Physics, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Therése KlingstedtDepartment of Physics, Chemistry and Biology, Linköping University, SE 581 83 Linköping, Sweden.
Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Ruben VidalDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Carolin KönigLeibniz University Hannover, Institute of Physical Chemistry and Electrochemistry, Callinstr. 3A, 30167 Hannover, Germany.ORCID 0000-0001-8931-4337
Mikael LindgrenDepartment of Physics, Norwegian University of Science and Technology, 7491 Trondheim, Norway.ORCID 0000-0001-6649-7871
K Peter R NilssonDepartment of Physics, Chemistry and Biology, Linköping University, SE-581 83 Linköping, Sweden.
Mathieu LinaresDepartment of Theoretical Chemistry and Biology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, SE-106 91 Stockholm, Sweden.ORCID 0000-0002-9720-5429
Patrick NormanDepartment of Theoretical Chemistry and Biology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, SE-106 91 Stockholm, Sweden.ORCID 0000-0002-1191-4954
KTH Royal Institute of Technology · SELinköping University · SEIndiana University School of MedicineLeibniz University Hannover · DENorwegian University of Science and Technology · NO

Funding

Atomic models of human tau filaments and development of tau ligandsU01NS110437 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2018 to 2022
$3.5M
NINDS NIH HHS U01 NS110437
6 · The paper itself

Abstract

The bi-thiophene-vinylene-benzothiazole (bTVBT4) ligand developed for Alzheimer's disease (AD)-specific detection of amyloid tau has been studied by a combination of several theoretical methods and experimental spectroscopies. With reference to the cryo-EM tau structure of the tau protofilament (

Indexed as

Alzheimer DiseasePick Disease of the BrainHumansLigandsProtein Bindingtau ProteinsLigandstau Proteins

Identifiers

PMID34643404
PMCPMC8558859
OpenAlexW3207624462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.