Evidence map›Paper›PMID 34643354›Full record

ArticleJournal of mother and child2021

The retrospective molecular analysis of large or giant congenital melanocytic nevi in a group of Polish children.

Katarzyna Wertheim-Tysarowska, Orest Szczygielski, Katarzyna Seliga, Andrzej Tysarowski, Jerzy Bal, Elżbieta Michalak, Agnieszka Magdalena Rygiel, Ewa Sawicka

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of mother and child, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Katarzyna Wertheim-TysarowskaInstitute of Mother and Child, Medical Genetics Department, Kasprzaka 17a, PL 01-211, Warsaw, Poland.ORCID https://orcid.org/0000-0001-9911-3811
Orest SzczygielskiClinic of Surgery of Children and Adolescents, Kasprzaka 17a, PL 01-211, Warsaw, Poland.ORCID https://orcid.org/0000-0001-6931-0769
Katarzyna SeligaMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Translational and Molecular Oncology Department, W. K. Roentgena 5, PL 02-781, Warsaw Poland.ORCID https://orcid.org/0000-0002-0358-3518
Andrzej TysarowskiMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Translational and Molecular Oncology Department, W. K. Roentgena 5, PL 02-781, Warsaw Poland.ORCID https://orcid.org/0000-0001-7726-490X
Jerzy BalInstitute of Mother and Child, Medical Genetics Department, Kasprzaka 17a, PL 01-211, Warsaw, Poland.ORCID https://orcid.org/0000-0001-7638-5128
Elżbieta MichalakInstitute of Mother and Child, Department of Pathology, Kasprzaka 17a, PL 01-211, Warsaw, Poland.ORCID https://orcid.org/0000-0002-5396-225X
Agnieszka Magdalena RygielInstitute of Mother and Child, Medical Genetics Department, Kasprzaka 17a, PL 01-211, Warsaw, Poland.ORCID https://orcid.org/0000-0002-3838-2900
Ewa SawickaClinic of Surgery of Children and Adolescents, Kasprzaka 17a, PL 01-211, Warsaw, Poland.ORCID https://orcid.org/0000-0002-1209-3924
Instytut Matki i Dziecka · PLThe Maria Sklodowska-Curie National Research Institute of Oncology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLarge and giant congenital melanocytic nevi (CMN), benign naevomelanocytic proliferations derived from neural crests, with a projected adult size (PAS) ≥ 20 cm, are connected to a high risk of melanoma and neurocutaneous melanosis. Among several factors, genetic alterations seem to be involved in tumorigenesis. The aim of the present study was to analyse the mutation status of MATERIAL AND

methodsThe formalin-fixed, paraffin-embedded resection specimens from 18 patients, fixed in the years of 2006 to 2017, were included in the study. The regions containing the highest load of melanocytes were macrodissected prior to DNA isolation. The

resultsWe detected activating mutations in

conclusionOur study, the first molecular analysis of large/giant CMN in Polish patients, supports the hypothesis that

Indexed as

Nevus, PigmentedSkin NeoplasmsAdultChildHumansNeoplasm Recurrence, LocalPolandRetrospective StudiesCMNCongenital melanocytic neviGCMNNRAS

Identifiers

PMID34643354
PMCPMC8603851
OpenAlexW3206622145

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.