Evidence map›Paper›PMID 34643283›Full record

ArticleThe Laryngoscope2022

Preoperative SARS-CoV-2 Screening Fails to Detect Viral Particles Prior to Airway Surgery.

Beth Osterbauer, Ronica Yalamanchili, Christian Hochstim, Marshall Ge, Jennifer Dien Bard, Elisabeth H Ference, Gabriel Gomez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Beth OsterbauerDivision of Otolaryngology-Head and Neck Surgery, Children's Hospital Los Angeles, Los Angeles, CA, U.S.A.ORCID 0000-0003-2774-3229
Ronica YalamanchiliDivision of Otolaryngology-Head and Neck Surgery, Children's Hospital Los Angeles, Los Angeles, CA, U.S.A.
Christian HochstimDivision of Otolaryngology-Head and Neck Surgery, Children's Hospital Los Angeles, Los Angeles, CA, U.S.A.
Marshall GeDepartment of Otolaryngology-Head and Neck Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA, U.S.A.
Jennifer Dien BardDepartment of Surgery at Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, U.S.A.
Elisabeth H FerenceDivision of Otolaryngology-Head and Neck Surgery, Children's Hospital Los Angeles, Los Angeles, CA, U.S.A.
Gabriel GomezDivision of Otolaryngology-Head and Neck Surgery, Children's Hospital Los Angeles, Los Angeles, CA, U.S.A.

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
NCATS NIH HHS UL1 TR001855
6 · The paper itself

Abstract

objectives/hypothesisChildren have higher rates of asymptomatic SARS-CoV-2 infections or milder courses of infection, and their carrier status may potentially impact viral transmission to those providing them care. The aim of this study is to compare the existing COVID-19 preoperative screening protocols to the detection of SARS-CoV-2 viral particles in surgical samples. STUDY

designCross-sectional study.

methodsWe conducted a prospective study with consecutive convenience sampling of children undergoing adenoidectomy between January and April 2021. Total nucleic acid was extracted from adenoid tissue and real-time reverse transcription-polymerase chain reaction was conducted to test for the presence of SARS-CoV-2 viral particles. Univariate logistic regression was used to summarize the effect size of variables of interest on the odds of having SARS-CoV-2 positive adenoid tissue.

resultsForty adenoid samples were collected and 11 (27.5%) had a positive SARS-CoV-2 reverse transcriptase-polymerase chain reaction. Patients with positive adenoids were older (11.8 vs. 7.9 years, odds ratio: 1.3, P = .01) and more likely to have had a positive nasopharyngeal swab in the previous 90 days (4/11 or 36% vs. 0).

conclusionThese data are the first report on the presence of SARS-CoV-2 particles in pediatric adenoidectomy specimens, with a high percentage of patients showing evidence of viral particles within the adenoid. This finding calls in to question the utility of preoperative COVID screening protocols which have yet to be rigorously validated in asymptomatic patients and have the potential to delay patients' surgical care. LEVEL OF EVIDENCE: 3 Laryngoscope, 132:1665-1667, 2022.

Indexed as

COVID-19SARS-CoV-2ChildClinical Laboratory TechniquesCOVID-19 TestingCross-Sectional StudiesHumansProspective StudiesVirionadenoidectomyChildCOVID-19SARS-CoV-2

Identifiers

PMID34643283
PMCPMC8661649

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.