Evidence map›Paper›PMID 34643147›Full record

ArticleJournal of dental research2022

Dementia and the Risk of Periodontitis: A Population-Based Cohort Study.

K S Ma, H Hasturk, I Carreras, A Dedeoglu, J J Veeravalli, J Y Huang, A Kantarci, J C Wei

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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  9. Relationship Between Periodontitis and Nitric Oxide in Patients Undergoing Maintenance Hemodialysis.Hemodialysis international. International Symposium on Home Hemodialysis · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

K S MaCenter for Global Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
H HasturkForsyth Institute, Cambridge, MA, USA.
I CarrerasDepartment of Veterans Affairs, VA Boston Healthcare System, Boston, MA, USA.
A DedeogluDepartment of Veterans Affairs, VA Boston Healthcare System, Boston, MA, USA.
J J VeeravalliDepartment of Life Science, National Taiwan University, Taipei.
J Y HuangInstitute of Medicine, Chung Shan Medical University, Taichung.
A KantarciForsyth Institute, Cambridge, MA, USA.
J C WeiInstitute of Medicine, Chung Shan Medical University, Taichung.
Boston University · USCenter for Global Health · USChung Shan Medical University · TWChung Shan Medical University Hospital · TWHarvard University · USNational Taiwan University · TWVA Boston Healthcare System · US

Funding

Mechanistic link between Alzheimer's disease and periodontitisRF1AG062496 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DEDEOGLU, ALPASLAN, KANTARCI, IBRAHIM ALPDOGAN · 2019 to 2019
$3.7M
NIA NIH HHS RF1 AG062496
6 · The paper itself

Abstract

Dementia and Alzheimer's disease (AD) are proposed to be comorbid with periodontitis (PD). It is unclear whether PD is associated with dementia and AD independent of confounding factors. We aimed at identifying the relationship between the longitudinal risk of developing PD in a cohort of patients with dementia and AD who did not show any signs of PD at baseline. In this retrospective cohort study, 8,640 patients with dementia without prior PD were recruited, and 8,640 individuals without dementia history were selected as propensity score-matched controls. A Cox proportional hazard model was developed to estimate the risk of developing PD over 10 y. Cumulative probability was derived to assess the time-dependent effect of dementia on PD. Of the 8,640 patients, a sensitivity test was conducted on 606 patients with AD-associated dementia and 606 non-AD propensity score-matched controls to identify the impact of AD-associated dementia on the risk for PD. Subgroup analyses on age stratification were included. Overall 2,670 patients with dementia developed PD. The relative risk of PD in these patients was significantly higher than in the nondementia group (1.825, 95% CI = 1.715 to 1.942). Cox proportional hazard models showed that patients with dementia were more likely to have PD than individuals without dementia (adjusted hazard ratio = 1.915, 95% CI = 1.766 to 2.077,

Indexed as

Alzheimer DiseasePeriodontitisCohort StudiesHumansProportional Hazards ModelsRetrospective StudiesRisk FactorsagedAlzheimer’s diseaseinflammatory responseneurodegenerative diseasesperiodontal diseasesperiodontal pocket

Identifiers

PMID34643147
PMCPMC8982009
OpenAlexW3206025441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.