Evidence map›Paper›PMID 34643006›Full record

SynthesisReviews in medical virology2022

The prevalence, predictors and outcomes of acute liver injury among patients with COVID-19: A systematic review and meta-analysis.

Harapan Harapan, Jonny Karunia Fajar, Supriono Supriono, Gatot Soegiarto, Laksmi Wulandari, Fiha Seratin, Nyoman Gede Prayudi, Dara Puspita Dewi, Maria Theresia Monica Elsina, Lasarus Atamou and 21 more

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Reviews in medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Liver Injury in Patients with COVID-19: A Retrospective Study.International journal of medical sciences · 2023
    Article
  12. COVID-19-Associated Liver Injury.Hepatic medicine : evidence and research · 2023
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 10 institutions in 1 country.

Harapan HarapanMedical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.ORCID https://orcid.org/0000-0001-7630-8413
Jonny Karunia FajarBrawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Supriono SuprionoDepartment of Internal Medicine, Division of Gastro-Entero-Hepatology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Gatot SoegiartoDepartment of Internal Medicine, Division of Allergy & Immunology, Universitas Airlangga, Surabaya, Indonesia.ORCID https://orcid.org/0000-0002-9197-3873
Laksmi WulandariDepartment of Pulmonology and Respiratory Medicine, Universitas Airlangga, Surabaya, Indonesia.
Fiha SeratinDepartment of Paediatric, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia.
Nyoman Gede PrayudiDepartment of Urology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Dara Puspita DewiFaculty of Public Health, Universitas Indonesia, Depok, Indonesia.
Maria Theresia Monica ElsinaFaculty of Nursing, Universitas Indonesia, Depok, Indonesia.
Lasarus AtamouFaculty of Nursing, Universitas Indonesia, Depok, Indonesia.
Sinta WiranataFaculty of Medicine, Universitas Udayana, Denpasar, Indonesia.
Dhito Pemi ApriantoFaculty of Public Health, Universitas Indonesia, Depok, Indonesia.
Erlin FriskaFaculty of Medicine, Universitas Indonesia, Depok, Indonesia.
D Fitria Sari FirdausFaculty of Medicine, Universitas Indonesia, Depok, Indonesia.
Makdum AlaidinDepartment of Nursing, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia.
Firdha Aprillia WardhaniFaculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Milda HusnahMaster Program of Biology, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia.
Nurdina Wahyu HidayatiFaculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Yeni HendriyantiFaculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Kristia WardaniBrawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Arde EvattaBrawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Reizal Audi ManuganBrawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Wiryawan PradiptoBrawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Ade RahmawatiBrawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Fredo TamaraBrawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Aditya Indra MahendraBrawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Firzan NainuFaculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.
Budi SantosoDepartment of Internal Medicine, RSUD Bangil, Pasuruan, Indonesia.
Chandra Adi Irawan PrimasatyaFaculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Nindy TjionganataDepartment of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Hendarto Arif BudimanFaculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
University of Brawijaya · IDUniversity of Indonesia · IDAirlangga University · IDUniversitas Gadjah Mada · IDUniversitas Syiah Kuala · IDDiponegoro University · IDHasanuddin University · IDPadjadjaran University · IDUdayana University · IDUniversity of Bangka Belitung · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The data on the predictors and prognosis of acute liver injury (ALI) among patients in coronavirus disease 2019 (COVID-19) patients are limited. The aim of this study was to determine the prevalence, predictors and outcomes of ALI among patients with COVID-19. A systematic review was conducted up to 10 June 2021. The relevant papers were searched from PubMed, Embase, Cochrane and Web of Science, and the data were analysed using a Z test. A total of 1331 papers were identified and 16 papers consisting of 1254 COVID-19 with ALI and 4999 COVID-19 without ALI were analysed. The cumulative prevalence of ALI among patients with COVID-19 was 22.8%. Male and having low lymphocyte levels were more likely to be associated with ALI compared with female and having higher lymphocyte level, odds ratio (OR): 2.70; 95% confidence interval (CI): 2.03, 3.60 and mean difference (MD) -125; 95% CI: -207, -43, respectively. COVID-19 patients with ALI had higher risk of developing severe COVID-19 compared with those without ALI (OR: 3.61; 95% CI: 2.60, 5.02). Our findings may serve as the additional evaluation for the management of ALI in COVID-19 patients.

Indexed as

COVID-19FemaleHumansLiverMalePrevalencePrognosisacute liver injuryCOVID-19outcomepredictorprevalence

Identifiers

PMID34643006
PMCPMC8646502
OpenAlexW3207682039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.