ArticleEpilepsia2021
Decoupling of functional and structural language networks in temporal lobe epilepsy.
Article in Epilepsia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Neuroimmune activation in temporal lobe epilepsy patients with worsening seizure following the COVID-19 pandemic: A [Science advances · 2026Article
- Abnormal Regional Brain Functional Activity and Brain Network Connectivity in Primary Trigeminal Neuralgia Patients: An Activation Likelihood Estimation Meta-Analysis Based on Resting-State fMRI.Journal of pain research · 2026Review
- Disparities in Connectivity Profiles Between Structural and Functional Networks in Patients With Temporal Lobe Epilepsy.Brain and behavior · 2025Article
- Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection.Nature communications · 2025Article
- Long-term neuroplasticity in language networks after anterior temporal lobe resection.Epilepsia · 2025Article
- Quantitative phenotyping of verbal and non-verbal cognitive impairment using diffusion-weighted MRI connectome: Preliminary study of the crowding effect in children with left hemispheric epilepsy.Epilepsy & behavior : E&B · 2024Article
- Predictors of long-term memory and network connectivity 10 years after anterior temporal lobe resection.Epilepsia · 2024Article
- The impact of bilateral versus unilateral anterior temporal lobe damage on face recognition, person knowledge and semantic memory.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Naming fMRI-guided white matter language tract volumes influence naming decline after temporal lobe resection.Journal of neurology · 2024Article
- Abnormal white matter structural network topological property in patients with temporal lobe epilepsy.CNS neuroscience & therapeutics · 2024Article
- Topological regularization of networks in temporal lobe epilepsy: a structural MRI study.Frontiers in neuroscience · 2024Article
- Social-semantic knowledge in frontotemporal dementia and after anterior temporal lobe resection.Brain communications · 2024Article
- Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study.Scientific reports · 2023Article
- Contribution of White Matter Fiber Bundle Damage to Language Change After Surgery for Temporal Lobe Epilepsy.Neurology · 2023Article
- Subcortical Functional Connectivity Gradients in Temporal Lobe Epilepsy.medRxiv : the preprint server for health sciences · 2023Article
- Structural-functional coupling abnormalities in temporal lobe epilepsy.Frontiers in neuroscience · 2023Article
- Review
- Resection of dominant fusiform gyrus is associated with decline of naming function when temporal lobe epilepsy manifests after the age of five: A voxel-based lesion-symptom mapping study.NeuroImage. Clinical · 2022Article
- Disruption of Cerebellar-Cerebral Functional Connectivity in Temporal Lobe Epilepsy and the Connection to Language and Cognitive Functions.Frontiers in neuroscience · 2022Article
- Decoupling of functional and structural language networks in temporal lobe epilepsy.Epilepsia · 2021Article
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
objectiveTo identify functional and structural alterations in language networks of people with temporal lobe epilepsy (TLE), who frequently present with naming and word-finding difficulties.
methodsFifty-five patients with unilateral TLE (29 left) and 16 controls were studied with auditory and picture naming functional magnetic resonance imaging (fMRI) tasks. Activation maxima in the left posterobasal temporal lobe were used as seed regions for whole-brain functional connectivity analyses (psychophysiological interaction). White matter language pathways were investigated using diffusion tensor imaging and neurite orientation dispersion and density imaging metrics extracted along fiber bundles starting from fMRI-guided seeds. Regression analyses were performed to investigate the correlation of functional connectivity with diffusion MRI metrics.
resultsIn the whole group of patients and controls, weaker functional connectivity from the left posterobasal temporal lobe (1) to the bilateral anterior temporal lobe, precentral gyrus, and lingual gyrus during auditory naming and (2) to the bilateral occipital cortex and right fusiform gyrus during picture naming was associated with decreased neurite orientation dispersion and higher free water fraction of white matter tracts. Compared to controls, TLE patients exhibited fewer structural connections and an impaired coupling of functional and structural metrics. SIGNIFICANCE: TLE is associated with an impairment and decoupling of functional and structural language networks. White matter damage, as evidenced by diffusion abnormalities, may contribute to impaired functional connectivity and language dysfunction in TLE.
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