Evidence map›Paper›PMID 34642910›Full record

ReviewReproductive sciences (Thousand Oaks, Calif.)2022

PCOS and Depression: Common Links and Potential Targets.

Jagruti V Kolhe, Abu Sufiyan Chhipa, Shital Butani, Vishal Chavda, Snehal S Patel

Abstract readReview
PubMed Publisher
In one paragraph

Review in Reproductive sciences (Thousand Oaks, Calif.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 6 pooled it
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 6 syntheses or guidelines pooled it, 105 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jagruti V KolheDepartment of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, 382481, Gujarat, India.
Abu Sufiyan ChhipaDepartment of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, 382481, Gujarat, India.
Shital ButaniDepartment of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, 382481, Gujarat, India.
Vishal ChavdaDepartment of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, 382481, Gujarat, India.
Snehal S PatelDepartment of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, 382481, Gujarat, India. snehal.patel@nirmauni.ac.in.ORCID 0000-0002-5002-7530
Nirma University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PCOS or polycystic ovary syndrome is a common endocrine disorder that occurs during the reproductive age in females. It manifests in the form of a wide range of symptoms including (but not limited to) hirsutism, amenorrhea, oligomenorrhea, obesity, acne vulgaris, infertility, alopecia, and insulin resistance. The incidence of depression in PCOS population is increasing as compared to the general population. Increased depression in PCOS significantly alters the quality of life (QOL) of affected females. Also, self-esteem is found to be low in both depression and PCOS. The loss in self-esteem in such patients can be largely attributed to the associated factors including (but not limited to) obesity, acne, androgenic alopecia, and hirsutism. The reason behind the occurrence of depression in PCOS remains elusive to date. Literature suggests that there is an overlap of clinical symptoms between depression and PCOS. As the symptoms overlap, there is a possibility of common associations between depression, PCOS, and PCOS-associated abnormalities including insulin resistance (IR), obesity, CVD, and androgen excess. Studies demonstrate that depression is an inflammatory disorder marked with increased levels of inflammatory markers. On the other hand, PCOS is also regarded as a pro-inflammatory state that is characterized by increased levels of pro-inflammatory markers. Thus, there is a possibility of an inflammatory relationship existing between depression and PCOS. It is also possible that the inflammatory markers in PCOS can cross the blood-brain barrier (BBB) leading to the development of depression. Through the present review, we have attempted to shed light on common associations/shared links between depression and PCOS with respect to the levels of cortisol, androgen, vitamin D, neurotransmitters, monoaminoxidase (MAO), and insulin-like growth factor-1 (IGF-1). Tracking down common associations between depression and PCOS will help find potential drug therapies and improve the QOL of females with depression in PCOS.

Indexed as

Acne VulgarisInsulin ResistancePolycystic Ovary SyndromeAlopeciaAndrogensDepressionFemaleHirsutismHumansObesityQuality of LifeAndrogensDepressionInflammationInsulin-like growth factor 1 (IGF-1)Insulin resistance (IR)ObesityPolycystic ovarian syndrome (PCOS)

Identifiers

PMID34642910
OpenAlexW3207676265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.