Evidence map›Paper›PMID 34642898›Full record

ArticleMolecular imaging and biology2022

In vivo Imaging of Cannabinoid Type 2 Receptors: Functional and Structural Alterations in Mouse Model of Cerebral Ischemia by PET and MRI.

Ruiqing Ni, Adrienne Müller Herde, Achi Haider, Claudia Keller, Georgios Louloudis, Markus Vaas, Roger Schibli, Simon M Ametamey, Jan Klohs, Linjing Mu

Open access · hybridAbstract read
In one paragraph

Article in Molecular imaging and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ruiqing NiInstitute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-0793-2113
Adrienne Müller HerdeDepartment of Chemistry and Applied Biosciences, ETH Zurich, HCI H427 Vladimir-Prelog-Weg 1-5/10, 8093, Zurich, Switzerland.
Achi HaiderDepartment of Chemistry and Applied Biosciences, ETH Zurich, HCI H427 Vladimir-Prelog-Weg 1-5/10, 8093, Zurich, Switzerland.
Claudia KellerDepartment of Chemistry and Applied Biosciences, ETH Zurich, HCI H427 Vladimir-Prelog-Weg 1-5/10, 8093, Zurich, Switzerland.
Georgios LouloudisInstitute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland.
Markus VaasInstitute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland.
Roger SchibliDepartment of Chemistry and Applied Biosciences, ETH Zurich, HCI H427 Vladimir-Prelog-Weg 1-5/10, 8093, Zurich, Switzerland.
Simon M AmetameyDepartment of Chemistry and Applied Biosciences, ETH Zurich, HCI H427 Vladimir-Prelog-Weg 1-5/10, 8093, Zurich, Switzerland.
Jan KlohsInstitute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland.
Linjing MuDepartment of Chemistry and Applied Biosciences, ETH Zurich, HCI H427 Vladimir-Prelog-Weg 1-5/10, 8093, Zurich, Switzerland. linjing.mu@pharma.ethz.ch.ORCID http://orcid.org/0000-0001-5354-1546
ETH Zurich · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeStroke is one of the most prevalent vascular diseases. Non-invasive molecular imaging methods have the potential to provide critical insights into the temporal dynamics and follow alterations of receptor expression and metabolism in ischemic stroke. The aim of this study was to assess the cannabinoid type 2 receptor (CB PROCEDURES: Our recently developed CB

resultsmRNA expressions of inflammatory markers TNF-α, Iba1, MMP9 and GFAP, CNR2 were increased to 1.3-2.5 fold at 24 h after reperfusion in the ipsilateral compared to contralateral hemisphere of tMCAO mice, while mRNA expression of the neuronal marker MAP-2 was markedly reduced to ca. 50 %. Reduced [

conclusionsThis study revealed an increased [

Indexed as

Brain IschemiaCannabinoidsAnimalsDisease Models, AnimalFluorodeoxyglucose F18GlucoseIschemiaMagnetic Resonance ImagingMatrix Metalloproteinase 9MicePositron-Emission TomographyReceptors, CannabinoidRNARNA, MessengerTissue DistributionTumor Necrosis Factor-alphaCannabinoidsFluorodeoxyglucose F18GlucoseMatrix Metalloproteinase 9Receptors, CannabinoidRNARNA, MessengerTumor Necrosis Factor-alpha[18F]RoSMA-18-d6Cannabinoid type 2 receptorIschemic strokeMagnetic resonance imagingNeuroinflammationPositron emission tomography

Identifiers

PMID34642898
PMCPMC9581861
OpenAlexW3161373229

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.