Evidence map›Paper›PMID 34642862›Full record

ArticleBiological trace element research2022

Protective Effect of Nanoselenium on Renal Oxidative Damage Induced by Mercury in Laying Hens.

Yan Ma, Binyao Cheng, Yumeng Li, Zhuosi Wang, Xiang Li, Ao Ren, Qiujue Wu, Doudou Zhu, Bingbing Ren

Abstract readRandomized Controlled Trial, Veterinary
PubMed Publisher
In one paragraph

Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Heavy metal toxicity in poultry: a comprehensive review.Frontiers in veterinary science · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yan MaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China. yma19880621@163.com.ORCID http://orcid.org/0000-0002-5924-1293
Binyao ChengCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Yumeng LiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Zhuosi WangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Xiang LiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Ao RenCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Qiujue WuCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Doudou ZhuCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Bingbing RenCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Henan University of Science and Technology · CN

Funding

phd research start-up fund of henan university of science and technology 13480086
6 · The paper itself

Abstract

This study investigated the effects of dietary nanoselenium (nano-Se) supplementation protecting from renal oxidative damages induced by mercury (Hg) exposure in laying hens. Furthermore, endoplasmic reticulum (ER) stress pathway was explored to reveal the protective mechanism of nano-Se. A total of 576 40-week-old Hyline-White laying hens were randomly allocated to 4 groups with 6 pens per group and 24 hens per pen. The experimental groups were as follows: control (basal diet), control + 27.0 mg/kg Hg, control + 5.0 mg/kg nano-Se, and Hg27.0 + 5.0 mg/kg nano-Se. The results revealed that dietary Hg exposure significantly reduced laying performance (P < 0.05) and egg quality (P < 0.05), whereas nano-Se supplementation partially reversed the reductions. Besides, dietary Hg exposure could induce histopathology damages and apoptosis in kidney, whereas nano-Se addition could alleviate these toxicities effectively. After Hg exposure, the activities and gene expressions of superoxidative dismutase (SOD) (P < 0.05), catalase (CAT) (P < 0.01), glutathione reductase (GR) (P < 0.05) and glutathione peroxidase (GSH-Px) (P < 0.05), and glutathione (GSH) content (P < 0.05) were significantly decreased, while the malondialdehyde (MDA) level was significantly increased (P < 0.05) in kidney. However, nano-Se supplementation partially reversed the levels and gene expressions of these antioxidant biomarkers in kidney. Furthermore, dietary Hg exposure significantly increased the gene expressions of PERK (P < 0.05), ATF4 (P < 0.05), CHOP (P < 0.05), IRE1α (P < 0.05), TRAF2 (P < 0.05), ASK1 (P < 0.05), Caspase-9 (P < 0.05), Caspase-8 (P < 0.05), Caspase-3 (P < 0.05), and Bax/Bcl-2 (P < 0.05), whereas nano-Se supplementation partially reversed these increases of gene expressions. In summary, this study provides evidence that dietary Hg exposure can induce renal oxidative damages, and elucidates an important role of ER stress pathway in nano-Se alleviating renal apoptosis in laying hens.

Indexed as

Dietary SupplementsKidneyOxidative StressSeleniumAnimalsAntioxidantsChickensFemaleGlutathioneMercuryProtective AgentsAntioxidantsGlutathioneMercuryProtective AgentsSeleniumEndoplasmic reticulum stress pathwayLaying hensMercuryNanoseleniumRenal oxidative damages

Identifiers

PMID34642862
OpenAlexW3206055777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.