Evidence map›Paper›PMID 34642831›Full record

ReviewMolecular biology reports2021

PER2: a potential molecular marker for hematological malignancies.

Huihui Jiang, Xin Yang, Miaomiao Mi, Xiaonan Wei, Hongyuan Wu, Yu Xin, Chengming Sun

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Circadian geneOpen life sciences · 2025
    Article
  4. Impact of Circadian ClockInternational journal of molecular sciences · 2024
    Article
  5. Biological clock regulation by theFrontiers in cell and developmental biology · 2024
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Huihui Jiang *Department of Laboratory Center, Yantai Yuhuangding Hospital Affiliated to Qingdao University, 20 Yuhuangding East Road, Yantai, 264000, Shandong, China.
Xin Yang *Department of Laboratory Center, Yantai Yuhuangding Hospital Affiliated to Qingdao University, 20 Yuhuangding East Road, Yantai, 264000, Shandong, China.
Miaomiao MiDepartment of Laboratory Center, Yantai Yuhuangding Hospital Affiliated to Qingdao University, 20 Yuhuangding East Road, Yantai, 264000, Shandong, China.
Xiaonan WeiDepartment of Laboratory Center, Qingdao Women and Children's Hospital, Qingdao, 266000, Shandong, China.
Hongyuan WuDepartment of Laboratory Center, Yantai Yuhuangding Hospital Affiliated to Qingdao University, 20 Yuhuangding East Road, Yantai, 264000, Shandong, China.
Yu XinBinzhou Medical University, Yantai, 264000, Shandong, China.
Chengming SunDepartment of Laboratory Center, Yantai Yuhuangding Hospital Affiliated to Qingdao University, 20 Yuhuangding East Road, Yantai, 264000, Shandong, China. chengmingsun@163.com.ORCID http://orcid.org/0000-0002-8065-9053
Qingdao University · CNBinzhou Medical University · CN

Funding

major scientific and technological innovation projects of shandong province of china 2019JZZY011018yantai science and technology plan project of china 2019MSGY133yantai science and technology plan project of china 2019YD004
6 · The paper itself

Abstract

Circadian rhythm is a periodic change of organism according to the law of external environment, which is manifested in metabolism, cell proliferation, physiology and behavior. In recent years, the role of circadian genes in the occurrence and progression of hematological malignancies have been continuously demonstrated. PER2 is the core component of the circadian rhythm playing an important role in regulating the circadian rhythm of the biological clock. This review summarizes the research progress of PER2 in hematological malignancies, especially leukemia, in order to better understand its role in hematological malignancies, and provide new ideas for clinical diagnosis and treatment.

Indexed as

Cell ProliferationCircadian RhythmAnimalsHematologic NeoplasmsHumansNeoplasm ProteinsPeriod Circadian ProteinsNeoplasm ProteinsPER2 protein, humanPeriod Circadian ProteinsCircadian geneLeukemiaLymphomaPER2

Identifiers

PMID34642831
OpenAlexW3205377045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.