ArticleEuropean radiology2022
Multiparametric quantitative MRI for the evaluation of dysthyroid optic neuropathy.
Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Current insights of applying MRI in Graves' ophthalmopathy.Frontiers in endocrinology · 2022Pooled it
- Relationship between serologically abnormal lipid metabolism and dysthyroid optic neuropathy in patients with thyroid-associated ophthalmopathy.Journal of endocrinological investigation · 2026Article
- The Diagnostic Value of Mean Apparent Propagator-MRI in Dysthyroid Optic Neuropathy: A Quantitative Analysis of the Entire Visual Pathway.CNS neuroscience & therapeutics · 2026Article
- Bibliometrics in thyroid eye disease.Journal of endocrinological investigation · 2026Article
- Clinical value of dual-energy CT parameters combined with morphological features in predicting graves' ophthalmopathy.BMC medical imaging · 2025Article
- A novel nomogram based on orbital MRI parameters for early prediction of dysthyroid optic neuropathy in thyroid-associated ophthalmopathy.BMC ophthalmology · 2025Article
- Diagnostic value of MRI and diffusion-weighted imaging in dysthyroid optic neuropathy: a cross-sectional study providing insights into predictive parameters and pathogenesis.Neuroradiology · 2025Article
- Multiparametric MRI for Diagnosing Dysthyroid Optic Neuropathy: Added Value of Magnetization Transfer Imaging.Korean journal of radiology · 2025Article
- Application progress of magnetic resonance imaging in thyroid associated ophthalmopathy.Frontiers in endocrinology · 2025Review
- Increased choroidal stromal area in patients with active Graves' ophthalmopathy based on binarisation method of optical coherence tomographic images.BMJ open ophthalmology · 2024Article
- Diagnosis of dysthyroid optic neuropathy: combined value of orbital MRI and intracranial visual pathway diffusion kurtosis imaging.European radiology · 2024Article
- Optic nerve compression associated with visual cortex functional alteration in dysthyroid optic neuropathy: A combined orbital and brain imaging study.CNS neuroscience & therapeutics · 2024Article
- Whole-orbit radiomics: machine learning-based multi- and fused- region radiomics signatures for intravenous glucocorticoid response prediction in thyroid eye disease.Journal of translational medicine · 2024Article
- Extraocular muscle volume index at the orbital apex with optic neuritis: a combined parameter for diagnosis of dysthyroid optic neuropathy.European radiology · 2023Article
- Aberrant spontaneous brain activity in patients with thyroid-associated ophthalmopathy with and without optic neuropathy: a resting-state functional MRI study.European radiology · 2023Article
- Reduced contrast sensitivity function correlated with superficial retinal capillary plexus impairment in early stage of dysthyroid optic neuropathy.Eye and vision (London, England) · 2023Article
- Increased Orbital Muscle Fraction Diagnosed by Semi-Automatic Volumetry: A Risk Factor for Severe Visual Impairment with Excellent Response to Surgical Decompression in Graves' Orbitopathy.Journal of personalized medicine · 2022Article
- Benefit of [18F]-FDG PET/CT for treatment-naïve nasopharyngeal carcinoma.European journal of nuclear medicine and molecular imaging · 2022Article
- Thyroid-associated ophthalmopathy: Using diffusion tensor imaging to evaluate visual pathway microstructural changes.Frontiers in neurology · 2022Article
- Multi-Parametric Diffusion Tensor Imaging of The Optic Nerve for Detection of Dysthyroid Optic Neuropathy in Patients With Thyroid-Associated Ophthalmopathy.Frontiers in endocrinology · 2022Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the ability of quantitative MRI parameters for predicting dysthyroid optic neuropathy (DON).
methodsWe retrospectively collected and analyzed the clinical features and 3.0 T MRI data of 59 patients with Graves orbitopathy (GO), with (n = 26) and without DON (n = 33). We compared MRI quantitative parameters, including the modified muscle index (mMI), proptosis, volume of intra-orbital fat, mean apparent diffusion coefficient value, and T2 value of the optic nerve among patients with and without DON. A logistic regression analysis was performed to identify the risk factors associated with DON. Moreover, we performed a receiver operating characteristic curve analysis and decision curve analysis to evaluate the diagnostic performance of the identified parameters for DON.
resultsWe studied 118 orbits (43 and 75 with and without DON, respectively). The mMI and mean T2 value of the optic nerve were significantly greater in orbits with DON (p < 0.001). A greater mMI at 21 mm (odds ratio (OR), 1.039; 95% confidence interval (CI): 1.019, 1.058) and higher mean T2 value of the optic nerve (OR, 1.035; 95% CI: 1.017, 1.054) were associated with a higher risk of DON. A model combining the mMI at 21 mm and mean T2 values for the optic nerve effectively predicted DON in patients with GO, with a sensitivity and specificity of 95.3% and 76%, respectively.
conclusionA quantitative MRI parameter combining the mMI at 21 mm and mean T2 value of the optic nerve can be an effective imaging marker for identifying DON. KEY POINTS: • Patients with GO and DON had greater mMI than those without DON. • Optic nerves in patients with DON demonstrated an increased T2 value. • The quantitative MRI parameter combining the mMI at 21 mm and mean T2 value of the optic nerve is the most effective method for diagnosing DON.
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