SynthesisMolecular psychiatry2022
Structural gray matter differences in Problematic Usage of the Internet: a systematic review and meta-analysis.
Synthesis in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- The resting-state brain activity signatures for addictive disorders.Med (New York, N.Y.) · 2024Pooled it
- Internet addiction-induced brain structure and function alterations: a systematic review and meta-analysis of voxel-based morphometry and resting-state functional connectivity studies.Brain imaging and behavior · 2023Pooled it
- Structural and Functional Neural Correlates in Individuals with Excessive Smartphone Use: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Disrupted Sensory-Motor Network Integrity in Excessive Online Gaming: Insight From Multimodal Morphometric Mapping.Brain and behavior · 2026Article
- Not All Screen Use is Equal: Shifting the Focus from Screen Time to Problematic Use in Child and Adolescent Well-Being Research.Clinical child and family psychology review · 2026Review
- Independent brain cortical signatures of risk for adolescent cannabis use and consequences of such use are moderated by sex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Difficulty in Attention Switching and Its Neural Basis in Problematic Smartphone Use.Brain sciences · 2025Article
- Microbes Saving Lives and Reducing Suffering.Microbial biotechnology · 2025Article
- Similarities and Differences in Neuroimaging.Advances in experimental medicine and biology · 2025Review
- Mom, dad, put down your phone and talk to me: how parental phubbing influences problematic internet use among adolescents.BMC psychology · 2024Article
- Connectome-based predictive modeling of Internet addiction symptomatology.Social cognitive and affective neuroscience · 2024Article
- High-dimensional Metaverse Platforms and the Virtually Extended Self.Journal of cognition · 2024Article
- Unravelling the Enigma: How Behavioural Addictions Alter the Developing Child Brain?Annals of neurosciences · 2023Article
- Neurobiological risk factors for problematic social media use as a specific form of Internet addiction: A narrative review.World journal of psychiatry · 2023Review
- Internet severity and activities addiction questionnaire (ISAAQ): Psychometrics of item response theory and clustering of online activities.Comprehensive psychiatry · 2023Article
- The Mediatory Role of the Boredom and Loneliness Dimensions in the Development of Problematic Internet Use.International journal of environmental research and public health · 2023Article
- Associations between levels of Internet Gaming Disorder symptoms and striatal morphology-replication and associations with social anxiety.Psychoradiology · 2022Article
- Pharmacological interventions for Problematic Usage of the Internet (PUI): A narrative review of current progress and future directions.Current opinion in behavioral sciences · 2022Article
- Proton magnetic resonance spectroscopy (MRS) in individuals with internet gaming.Frontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Problematic Usage of the Internet (PUI) has been linked to diverse structural gray matter changes in individual data studies. However, no quantitative synthesis across studies has been conducted. We aimed to identify gray matter regions showing significant spatial convergence across neuroimaging studies in PUI. We searched PubMed and PsycINFO up to 10/03/2021 and included original, cross-sectional comparative studies that examined structural gray matter imaging in PUI versus control groups; reported a whole-brain analysis; and provided peak coordinates for gray matter differences. From a total of 624 potentially relevant studies, 15 (including 355 individuals with PUI and 363 controls) were included in a meta-analysis of voxel-based morphometry studies. Anatomical likelihood estimation (ALE) meta-analysis was performed using extracted coordinates and identified significant spatial convergence in the medial/superior frontal gyri, the left anterior cingulate cortex/cingulate gyrus, and the left middle frontal/precentral gyri. Datasets contributing to these findings all indicated reduced gray matter in cases compared to controls. In conclusion, voxel-based morphometric studies indicate replicable gray matter reductions in the dorsolateral prefrontal cortex and anterior cingulate cortex in PUI, regions implicated in reward processing and top-down inhibitory control. Further studies are required to understand the nature of gray matter differences across PUI behaviors, as well as the contribution of particular mental health disorders, and the influence of variation in study and sample characteristics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.