ArticleScientific reports2021
Imaging characteristics of young age breast cancer (YABC) focusing on pathologic correlation and disease recurrence.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A preoperative nomogram incorporating semantic MRI features for predicting breast cancer recurrence: a propensity score-matched cohort study.Frontiers in oncology · 2026Article
- Prognostic Role of Preoperative Axillary Ultrasound for Lymph Node Metastasis and Recurrence in Early Stage Breast Cancers.Journal of breast cancer · 2025Article
- An Institutional Survey of Early-Onset Breast Cancer in Young Women With Imaging and Molecular Subtype Correlation.Cureus · 2025Article
- Prognosis of Breast Cancer in Women in Their 20s: Clinical and Radiological Insights.Diagnostics (Basel, Switzerland) · 2025Article
- The impact of radiogenomics on breast cancer.American journal of cancer research · 2025Review
- Clinical and pathological characteristics and prognosis analysis of breast cancer patients stratified by age.American journal of translational research · 2025Article
- A predictive model using MRI and clinicopathologic features for breast cancer recurrence in young women treated with upfront surgery.European radiology · 2024Article
- Ready the treasure at our feet, MRI feature analysis in young women with breast cancer.European radiology · 2024Article
- Radiomics Nomogram: Prediction of 2-Year Disease-Free Survival in Young Age Breast Cancer.Cancers · 2022Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study is to investigate imaging characteristics of young age breast cancer (YABC) focusing on correlation with pathologic factors and association with disease recurrence. From January 2017 to December 2019, patients under 40 years old who were diagnosed as breast cancer were enrolled in this study. Morphologic analysis of tumor and multiple quantitative parameters were obtained from pre-treatment dynamic contrast enhanced breast magnetic resonance imaging (DCE-MRI). Tumor-stroma ratio (TSR), microvessel density (MVD) and endothelial Notch 1 (EC Notch 1) were investigated for correlation with imaging parameters. In addition, recurrence associated factors were assessed using both clinico-pathologic factors and imaging parameters. A total of 53 patients were enrolled. Several imaging parameters derived from apparent diffusion coefficient (ADC) histogram showed negative correlation with TSR; and there was negative correlation between MVD and Ve in perfusion analysis. There were nine cases of recurrences with median interval of 16 months. Triple negative subtype and low CD34 MVD positivity in Notch 1 hotspots showed significant association with tumor recurrence. Texture parameters reflecting tumor sphericity and homogeneity were also associated with disease recurrence. In conclusion, several quantitative MRI parameters can be used as imaging biomarkers for tumor microenvironment and can predict disease recurrence in YABC.
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