Evidence map›Paper›PMID 34642371›Full record

ArticleScientific reports2021

Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19.

Trang T Le, Alba Gutiérrez-Sacristán, Jiyeon Son, Chuan Hong, Andrew M South, Brett K Beaulieu-Jones, Ne Hooi Will Loh, Yuan Luo, Michele Morris, Kee Yuan Ngiam and 13 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  13. A Review of Neurological Involvement in Patients with SARS-CoV-2 Infection.Medical science monitor : international medical journal of experimental and clinical research · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 20 institutions in 10 countries.

Trang T Le *Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Alba Gutiérrez-Sacristán *Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Jiyeon Son *Department of Neurology, University of Pittsburgh, Biomedical Science Tower 3, Suite 7014, 3501 5th Avenue, Pittsburgh, PA, 15260, USA.
Chuan HongDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Andrew M SouthDepartment of Pediatrics, Wake Forest School of Medicine, Winston Salem, NC, USA.
Brett K Beaulieu-JonesDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Ne Hooi Will LohDepartment of Critical Care, National University Health Systems, Singapore, Singapore.
Yuan LuoDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.
Michele MorrisDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Kee Yuan NgiamDepartment of Surgery, National University Health Systems, Singapore, Singapore.
Lav P PatelDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Malarkodi J SamayamuthuDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Emily SchriverData Analytics Center, University of Pennsylvania Health System, Philadelphia, PA, USA.
Amelia L M TanDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Jason MooreDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Tianxi CaiDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Gilbert S OmennDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Paul AvillachDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Isaac S KohaneDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Consortium for Clinical Characterization of COVID-19 by EHR (4CE)
Shyam VisweswaranDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Danielle L MoweryDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Zongqi XiaDepartment of Neurology, University of Pittsburgh, Biomedical Science Tower 3, Suite 7014, 3501 5th Avenue, Pittsburgh, PA, 15260, USA. zxia1@post.harvard.edu.
Harvard University · USUniversité Sorbonne Paris Nord · FRHospital Universitario 12 De Octubre · ESUniversity of Freiburg · DEMagna Graecia University · ITUniversidade Estadual Paulista (Unesp) · BRUniversity of Michigan · USBoston Children's Hospital · USGreat Ormond Street Hospital · GBUniversity of Pennsylvania · USChildren's Hospital of Philadelphia · USCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRMedical University of South Carolina · USUniversity of Pittsburgh · USAssistance Publique – Hôpitaux de Paris · FRInserm · FRUniversity of Kentucky · USCommunity Catalyst · USIstituti Clinici Scientifici Maugeri · ITMassachusetts General Hospital · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
RADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in Covid-19 TestingUL1TR002366 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mario Castro, JAMES STEVEN LEEDER · 2017 to 2026
$44.3M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STUART A BATTERMAN · 2011 to 2026
$21.5M
Leveraging electronic health records to optimize treatment selection and response in multiple sclerosisR01NS098023 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Zongqi Xia · 2016 to 2026
$4.6M
University of Michigan Proteogenomics Data Analysis CenterU24CA210967 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M, DHANASEKARAN, SARAVANA M · 2016 to 2020
$4.1M
Development and Evaluation of a Learning Electronic Medical Record SystemR01LM012095 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VISWESWARAN, SHYAM · 2015 to 2018
$1.8M
Predoctoral Training Program in Biomedical Data Driven Discovery (BD3)T32LM012203 · NLM · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KLABJAN, DIEGO, STARREN, JUSTIN B. · 2015 to 2019
$1.1M
The role of angiotensin-(1-7) in hypertension and hypertension-induced heart and kidney damageK23HL148394 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SOUTH, ANDREW MICHAEL · 2020 to 2024
$783k
British Heart Foundation FS/19/52/34563Medical Research Council MC_PC_18034NCATS NIH HHS CTSA Award #UL1TR001878NCATS NIH HHS CTSA Award #UL1TR002366NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1TR001420NCATS NIH HHS UL1 TR001422NCATS NIH HHS UL1 TR001857NCATS NIH HHS UL1TR001857NCATS NIH HHS UL1 TR001878NCATS NIH HHS UL1 TR002366NCI NIH HHS U24 CA210967NHLBI NIH HHS K23 HL148394NHLBI NIH HHS K23HL148394NHLBI NIH HHS L40 HL148910NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P30ES017885NINDS NIH HHS R01 NS098023NINDS NIH HHS R01NS098023NLM NIH HHS R01 LM012095NLM NIH HHS T32 LM012203
6 · The paper itself

Abstract

Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we used electronic health records (EHR) from 338 participating hospitals across 6 countries and 3 continents (January-September 2020) for a cross-sectional analysis. We assessed the frequency of International Classification of Disease code of neurological conditions by countries, healthcare systems, time before and after admission for COVID-19 and COVID-19 severity. Among 35,177 hospitalized patients with SARS-CoV-2 infection, there was an increase in the proportion with disorders of consciousness (5.8%, 95% confidence interval [CI] 3.7-7.8%, p

Indexed as

COVID-19Nervous System DiseasesPandemicsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolCross-Sectional StudiesFemaleHumansInfantInfant, NewbornMaleMiddle Aged

Identifiers

PMID34642371
PMCPMC8510999
OpenAlexW3207775241

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.