ArticleScientific reports2021
Identification and characterization of a novel Enterococcus bacteriophage with potential to ameliorate murine colitis.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
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- Updating the Discontinuity Theory to the Extended Immunity: The Symmunobiome Concept.European journal of immunology · 2025Review
- Potential value and research frontiers of viruses in inflammatory bowel diseases: a bibliometric analysis.Frontiers in microbiology · 2025Article
- Isolation and Characterization of NovelBiomedicines · 2024Article
- Phage therapy: Targeting intestinal bacterial microbiota for the treatment of liver diseases.JHEP reports : innovation in hepatology · 2023Review
- Isolation and characterization of a novel Enterococcus phage Phi_Eg_SY1.Virus research · 2023Article
- Murine scald models characterize the role of neutrophils and neutrophil extracellular traps in severe burns.Frontiers in immunology · 2023Article
- Microbiome-based interventions to modulate gut ecology and the immune system.Mucosal immunology · 2022Review
- Rehabilitation of a misbehaving microbiome: phages for the remodeling of bacterial composition and function.iScience · 2022Review
- Bacteriophage-mediated manipulations of microbiota in gastrointestinal diseases.Frontiers in microbiology · 2022Review
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Authors and funding
16 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increase of the enteric bacteriophages (phage), components of the enteric virome, has been associated with the development of inflammatory bowel diseases. However, little is known about how a given phage contributes to the regulation of intestinal inflammation. In this study, we isolated a new phage associated with Enterococcus gallinarum, named phiEG37k, the level of which was increased in C57BL/6 mice with colitis development. We found that, irrespective of the state of inflammation, over 95% of the E. gallinarum population in the mice contained phiEG37k prophage within their genome and the phiEG37k titers were proportional to that of E. gallinarum in the gut. To explore whether phiEG37k impacts intestinal homeostasis and/or inflammation, we generated mice colonized either with E. gallinarum with or without the prophage phiEG37k. We found that the mice colonized with the bacteria with phiEG37k produced more Mucin 2 (MUC2) that serves to protect the intestinal epithelium, as compared to those colonized with the phage-free bacteria. Consistently, the former mice were less sensitive to experimental colitis than the latter mice. These results suggest that the newly isolated phage has the potential to protect the host by strengthening mucosal integrity. Our study may have clinical implication in further understanding of how bacteriophages contribute to the gut homeostasis and pathogenesis.
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