Evidence map›Paper›PMID 34642320›Full record

ArticleCell death & disease2021

Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.

You Wang, Jinxian Yuan, Xinyuan Yu, Xi Liu, Changhong Tan, Yangmei Chen, Tao Xu

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Identification of plasma SEMA3E as the diagnostic biomarker for human epilepsy based on integrated bioinformatics analysis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  3. Article
  4. Mitochondria-related HSDL2 is a potential biomarker in temporal lobe epilepsy by modulating astrocytic lipid metabolism.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Article
  5. Article
  6. VezA/vezatin facilitates proper assembly of the dynactin complex in vivo.bioRxiv : the preprint server for biology · 2024
    Article
  7. Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

You Wang *Department of Neurology, the Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.
Jinxian Yuan *Department of Neurology, the Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.
Xinyuan YuDepartment of Neurology, Chongqing Hospital of Traditional Chinese Medicine, 400021, Chongqing, China.
Xi LiuDepartment of Neurology, the Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.
Changhong TanDepartment of Neurology, the Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.
Yangmei ChenDepartment of Neurology, the Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.
Tao XuDepartment of Neurology, the Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China. xutao@hospital.cqmu.edu.cn.ORCID 0000-0001-6006-5621
Dalian Medical University · CNFirst People's Hospital of Chongqing · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81771390National Natural Science Foundation of China (National Science Foundation of China) 81901315National Natural Science Foundation of China (National Science Foundation of China) 81901330
6 · The paper itself

Abstract

Although many studies have explored the mechanism of epilepsy, it remains unclear and deserves further investigation. Vezatin has been reported to be a synaptic regulatory protein involved in regulating neuronal synaptic transmission (NST). However, the role of vezatin in epilepsy remains unknown. Therefore, the aims of this study are to investigate the underlying roles of vezatin in epilepsy. In this study, vezatin expression was increased in hippocampal tissues from pilocarpine (PILO)-induced epileptic mice and a Mg

Indexed as

AnimalsCarrier ProteinsCyclic AMP-Dependent Protein KinasesDisease Models, AnimalEpilepsyExcitatory Postsynaptic PotentialsGene Knockdown TechniquesHippocampusLentivirusMaleMembrane ProteinsMiceMice, Inbred C57BLModels, BiologicalNeuronsPhosphorylationCarrier ProteinsCyclic AMP-Dependent Protein KinasesMembrane ProteinsPhosphoserinePilocarpineProtein SubunitsReceptors, AMPAReceptors, N-Methyl-D-Aspartatevezatin protein, mouseVEZT protein, human

Identifiers

PMID34642320
PMCPMC8511046
OpenAlexW3205285215

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.