ArticleNature communications2021
The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Frequencies of BCR::ABL1 Transcripts in Patients with Chronic Myeloid Leukemia: A Meta-Analysis.Genes · 2024Pooled it
- Whole genome sequencing of 1427 Mexican individuals from the oriGen cohort.Nature communications · 2026Article
- Genetic Diversity Analysis of Risk Variants Associated with Bone and Cartilage Metabolism in Nine Mexican Subpopulations.Biomedicines · 2026Article
- Type 2 diabetes genetics in 125,000 admixed adults from Mexico City.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Demographic History of Indigenous Populations in Mexico Explored Through Whole Mitogenome Analysis.Genome biology and evolution · 2026Article
- Association study uncovers obesity-linked variants in mobile elements as potential regulators of gene expression.iScience · 2026Article
- First Latin American Case of MLASA2 Caused by a Pathogenic Variant in the Anticodon-Binding Domain ofInternational journal of molecular sciences · 2025Article
- Genetic and genomic insights of the Comcáac people.Journal of community genetics · 2025Review
- Blood Pressure and Mortality in Mexico City: A Mendelian Randomization Study.Hypertension (Dallas, Tex. : 1979) · 2025Article
- A Pilot Study: Contrasting Genomic Profiles of Lung Adenocarcinoma Between Patients of European and Latin American Ancestry.International journal of molecular sciences · 2025Article
- Predicted risk genotypes to cardiovascular diseases based on cholesterol ester transfer protein (CETP -rs708272) and lipoprotein lipase (LPL -rs13702) variants in worldwide populations: highest risk in populations with Native American ancestry.Molecular biology reports · 2025Article
- Genome-Wide Selection Scans in Mexican Indigenous Populations Reveal Recent Signatures of Pathogen and Diet Adaptation.Genome biology and evolution · 2025Article
- The fat-mass and obesity-associated gene rs9939609 T allele is prominent among the native Mexican population and is associated with risk for Type 2 diabetes and metabolic dysfunction-associated steatotic liver disease.Frontiers in nutrition · 2025Article
- Application of next-generation sequencing to determine mutations in candidate genes for congenital eye malformations in the Mexican indigenous population.Frontiers in genetics · 2025Article
- Scientists and scientific journals should adhere to ethical standards for the use and reporting of data from Indigenous people.Diabetologia · 2024Article
- Association of total and free testosterone with cardiovascular disease in a nationally representative sample of white, black, and Mexican American men.International journal of impotence research · 2024Article
- Cross-cultural perception of strength, attractiveness, aggressiveness and helpfulness of Maasai male faces calibrated to handgrip strength.Scientific reports · 2024Article
- The Mexican Biobank Project promotes genetic discovery, inclusive science and local capacity building.Disease models & mechanisms · 2024Article
- Personalized medicine and nutrition in hepatology for preventing chronic liver disease in Mexico.Frontiers in nutrition · 2024Review
Corrections and comments
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Authors and funding
40 authors.
Funding
Abstract
The genetic makeup of Indigenous populations inhabiting Mexico has been strongly influenced by geography and demographic history. Here, we perform a genome-wide analysis of 716 newly genotyped individuals from 60 of the 68 recognized ethnic groups in Mexico. We show that the genetic structure of these populations is strongly influenced by geography, and our demographic reconstructions suggest a decline in the population size of all tested populations in the last 15-30 generations. We find evidence that Aridoamerican and Mesoamerican populations diverged roughly 4-9.9 ka, around the time when sedentary farming started in Mesoamerica. Comparisons with ancient genomes indicate that the Upward Sun River 1 (USR1) individual is an outgroup to Mexican/South American Indigenous populations, whereas Anzick-1 was more closely related to Mesoamerican/South American populations than to those from Aridoamerica, showing an even more complex history of divergence than recognized so far.
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