ArticleNature communications2021
Anti-Markovnikov hydro(amino)alkylation of vinylarenes via photoredox catalysis.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Practical Ni-Catalyzed Synthesis of Allylic Boronates.ACS omega · 2026Article
- Recyclable MnACS omega · 2026Article
- Photocatalytic 1,3-difluoroalkylcarboxylation of alkenes by triple kinetic-controlled radical self-ordering.Chemical science · 2025Article
- Chemoselective Cu-Catalyzed Cross-Nucleophile Alkylarylation of Alkenes.ACS catalysis · 2024Article
- Hydroalkylation of styrenes enabled by boryl radical mediated halogen atom transfer.Chemical science · 2024Article
- Synthesis of Pleuromutilin.Journal of the American Chemical Society · 2022Article
- Regio-, Diastereo-, and Enantioselective Decarboxylative Hydroaminoalkylation of Dienol Ethers Enabled by Dual Palladium/Photoredox Catalysis.Angewandte Chemie (International ed. in English) · 2022Article
- Photoredox-Catalyzed Oxidation of Anions for the Atom-Economical Hydro-, Amido-, and Dialkylation of Alkenes.The Journal of organic chemistry · 2022Article
- Photocatalytic Hydroaminoalkylation of Styrenes with Unprotected Primary Alkylamines.Journal of the American Chemical Society · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Photoredox catalysis is a powerful means to generate odd-electron species under mild reaction conditions from a wide array of radical precursors. Herein, we present the application of this powerful catalytic manifold to address the hydroalkylation and hydroaminoalkylation of electronically diverse vinylarenes. This reaction allows for generalized alkene hydroalkylation leveraging common alkyl radical precursors, such as organotrifluoroborate salts and carboxylic acids. Furthermore, utilizing easily accessible α-silyl amine reagents or tertiary amines directly, secondary and tertiary amine moieties can be installed onto monoaryl and diaryl alkenes to access valuable products, including γ,γ-diarylamines pharmacophores. Thus, under a unified system, both hydroalkylation and hydroaminoalkylation of alkenes are achieved. The substrate scope is evaluated through 57 examples, the synthetic utility of the method is demonstrated, and preliminary mechanistic insights are presented.
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