Evidence map›Paper›PMID 34642278›Full record

ArticleJournal of neurogastroenterology and motility2021

Heartburn, Functional Dyspepsia, Anxiety/Depression, and Sleep Disturbances Are Associated With Clinically Significant Belching.

Yasuhiro Fujiwara, Masatsugu Okuyama, Yasuaki Nagami, Koichi Taira, Hirotaka Ishizu, Osamu Takaishi, Hiroshi Sato, Toshio Watanabe

Open access · diamondAbstract read
In one paragraph

Article in Journal of neurogastroenterology and motility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Belching and Reflux: The Relationship and the Underlying Mechanism.Journal of neurogastroenterology and motility · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yasuhiro FujiwaraDepartment of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Masatsugu OkuyamaDepartment of Gastroenterology, Kashiwara Municipal Hospital, Kashiwara, Japan.
Yasuaki NagamiDepartment of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Koichi TairaDepartment of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Hirotaka IshizuDepartment of Gastroenterology, Kashiwara Municipal Hospital, Kashiwara, Japan.
Osamu TakaishiDepartment of Gastroenterology, Kashiwara Municipal Hospital, Kashiwara, Japan.
Hiroshi SatoDepartment of Gastroenterology, Kashiwara Municipal Hospital, Kashiwara, Japan.
Toshio WatanabeDepartment of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Kashiwa Municipal Hospital · JPOsaka City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsBelching is the act of expelling gas from the stomach or esophagus noisily through the oral cavity. Although it is a physiological phenomenon, belching may also be a symptom of upper gastrointestinal diseases such as reflux esophagitis and functional dyspepsia (FD). A detailed epidemiology of belching has not yet been reported. The aim of this study is to examine the prevalence and clinical characteristics of clinically significant belching (CSB) in adults.

methodsWe analyzed 1998 subjects who visited the hospital for annual health checkups. Belching was evaluated by a simple question "Do you burp a lot?" and scored as 0 (never), 1 (occasionally), 2 (sometimes), 3 (often), or 4 (always). Subjects with CSB were defined as having scores ≥ 3. We also collected the clinical parameters, endoscopic findings, and data according to the Athens Insomnia Scale, Rome IV questionnaire, and Hospital Anxiety and Depression Scale (HADS).

resultsOf the 1998 subjects, 121 (6.1%) had CSB. Subjects with CSB had FD more commonly than reflux esophagitis, but presence of heartburn was high (10.7% vs 3.1%). In addition, the HADS and Athens Insomnia Scale scores in subjects with CSB were significantly higher than those in subjects without CSB. Presence of heartburn (OR, 2.07; 95% CI, 1.05-4.09), presence of FD (OR, 2.12; 95% CI, 1.33-3.36), anxiety/depression (OR, 2.29; 95% CI 1.51-3.45), and sleep disturbances (OR, 1.73; 95% CI, 1.14-2.61) were significantly associated with CSB.

conclusionThe detailed epidemiology of belching in the general adult population was clarified.

Indexed as

AnxietyDepressionDyspepsiaEructationSleep

Identifiers

PMID34642278
PMCPMC8521483
OpenAlexW3205790536

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.