Observational studyCMAJ open
Risks associated with colonoscopy in a population-based colon screening program: an observational cohort study.
Observational study in CMAJ open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Surveillance After Pelvic Exenteration: A Systematic Review of Oncological and Functional Follow-Up.ANZ journal of surgery · 2026Pooled it
- Pneumopericardium and multicompartmental air dissemination after colorectal endoscopic resection managed conservatively: a case report.Frontiers in medicine · 2026Article
- Changes in Colorectal Cancer Screening Modalities Among Insured Individuals.JAMA network open · 2025Article
- Review
- Chronic Kidney Disease Increases Risk of Delayed Post-Polypectomy Bleeding: A Large-Scale Propensity Score-Matched Analysis.United European gastroenterology journal · 2025Article
- Identification and evaluation of a serum microRNA panel to diagnose colorectal cancer patients.International journal of cancer · 2025Article
- A Program Offering CT Colonography for Colorectal Cancer Screening Avoided Colonoscopy and Sedation Risks in Heart Transplant Candidates and Expedited Screening: A Retrospective Observational Study.Gastro hep advances · 2025Review
- A cell-free DNA colorectal cancer screening test promising enhanced accessibility and early detection.International journal of colorectal disease · 2024Review
- Screening for Colorectal Carcinoma in India: Real-World Scenario, Pitfalls, and Solutions.South Asian journal of cancer · 2024Article
- Post-polypectomy surveillance: follow-up recommendations from the Alberta Colorectal Cancer Screening Program.Journal of the Canadian Association of Gastroenterology · 2024Article
- Periprocedural Anticoagulation Management of Patients Undergoing Colonoscopy with Polypectomy.TH open : companion journal to thrombosis and haemostasis · 2024Article
- Ethics of early detection of disease risk factors: A scoping review.BMC medical ethics · 2024Article
- Article
- Adenoma Detection Rate in Colonoscopic Screening with Ketamine-based Sedation: A Prospective Observational Study.Medeniyet medical journal · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe risks associated with colonoscopy performed through the British Columbia Colon Screening Program (BCCSP) are not known. We aimed to determine the rate of colonoscopy-related serious adverse events within this program.
methodsFor this prospective observational study, we used the BCCSP database to identify participants 50 to 74 years of age who had a positive result on fecal immunochemical testing (FIT) between Nov. 15, 2013, and Dec. 31, 2017, followed by colonoscopy. Unplanned medical events were recorded at the time of colonoscopy and 14 days later. We reviewed the unplanned events and defined them as serious adverse events if they resulted in death, hospital admission or intervention; we also classified them as probably, possibly or unlikely related to the colonoscopy. The primary outcome was the overall rate of serious adverse events; the secondary outcomes were 14-day post-colonoscopy rates of perforation, bleeding and death.
resultsDuring the study period, a total of 96 192 colonoscopies were performed by 308 physicians at 50 sites. The median age of patients was 62 (10th-90th percentile 52-71) years, and 56% were male. Of these, 78 831 patients were contacted after the colonoscopy. Serious adverse events were deemed to have occurred in 350 colonoscopies (44 per 10 000, 95% confidence interval [CI] 39-50 per 10 000), with a number needed to harm of 225. Of the 332 (94.9%) serious adverse events that were probably or possibly related to colonoscopy, perforation occurred in 6 (95% CI 5-8) per 10 000 colonoscopies, bleeding in 26 (95% CI 22-30) per 10 000 colonoscopies and death in 3 (95% CI 1-10) per 100 000 colonoscopies.
interpretationThe rate of serious adverse events associated with colonoscopy in the BCCSP was in keeping with previous publications and met accepted benchmarks. The findings of this study inform stakeholders of the risks associated with colonoscopy in an FIT-based colon screening program.
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