Evidence map›Paper›PMID 34642249›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Synapse development is regulated by microglial THIK-1 K

Pablo Izquierdo, Hiroko Shiina, Chanawee Hirunpattarasilp, Grace Gillis, David Attwell

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Gating mechanism of the two-pore-domain potassium channel THIK1.Nature structural & molecular biology · 2025
    Article
  7. Cryo-EM structure of the human THIK-1 K2P KNature structural & molecular biology · 2025
    Article
  8. Structure of the human KNature structural & molecular biology · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Structure of the human KbioRxiv : the preprint server for biology · 2024
    Article
  13. Review
  14. Article
  15. Microglia: Activity-dependent regulators of neural circuits.Annals of the New York Academy of Sciences · 2024
    Review
  16. Differential contribution of THIK-1 KJournal of neuroinflammation · 2024
    Article
  17. Article
  18. Functional Potassium Channels in Macrophages.The Journal of membrane biology · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pablo IzquierdoDepartment of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom.ORCID 0000-0003-4372-348X
Hiroko ShiinaDepartment of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom.ORCID 0000-0003-4016-2285
Chanawee HirunpattarasilpDepartment of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom.
Grace GillisDepartment of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom.ORCID 0000-0002-6123-3647
David AttwellDepartment of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom d.attwell@ucl.ac.uk.ORCID 0000-0003-3618-0843

Funding

Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCalciumFemaleMaleMiceMicrogliaPotassium Channels, Tandem Pore DomainRatsRats, Sprague-DawleySynapsesCalciumKcnk13 protein, mousePotassium Channels, Tandem Pore Domainmicrogliaphagocytosissynaptic pruning

Identifiers

PMID34642249
PMCPMC8545484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.