Evidence map›Paper›PMID 34642225›Full record

ArticleeNeuro

An Automated Approach to Improve the Quantification of Pericytes and Microglia in Whole Mouse Brain Sections.

Jo-Maree Courtney, Gary P Morris, Elise M Cleary, David W Howells, Brad A Sutherland

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
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  4. Quantification of the neuropathology of alcohol use disorder using tissue microarrays.Journal of neuropathology and experimental neurology · 2026
    Article
  5. Digital neuropathology of neurodegenerative disorders: Foundations, research advances, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  6. Quantification of Alzheimer disease neuropathology using tissue microarrays.Journal of neuropathology and experimental neurology · 2025
    Article
  7. Article
  8. Article
  9. Differential Activation States of Direct Pathway Striatal Output Neurons during l-DOPA-Induced Dyskinesia Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
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  12. Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jo-Maree CourtneyTasmanian School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, 7000, Australia.
Gary P MorrisTasmanian School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, 7000, Australia.
Elise M ClearyTasmanian School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, 7000, Australia.
David W HowellsTasmanian School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, 7000, Australia.
Brad A SutherlandTasmanian School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, 7000, Australia brad.sutherland@utas.edu.au.
University of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whole slide scanning technology has enabled the generation of high-resolution images from complete tissue sections. However, commonly used analysis software is often unable to handle the large data files produced. Here, we present a method using the open-source software QuPath to detect, classify and quantify fluorescently-labeled cells (microglia and pericytes) in whole coronal brain tissue sections. Whole-brain sections from both male and female NG2DsRed x CX

Indexed as

MicrogliaPericytesAnimalsBrainFemaleHistological TechniquesImage Processing, Computer-AssistedMaleMicebraincell countingimage analysismicrogliapericytesQuPath

Identifiers

PMID34642225
PMCPMC8570687
OpenAlexW3206761874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.