Evidence map›Paper›PMID 34642214›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Schizophrenia-Linked Protein tSNARE1 Regulates Endosomal Trafficking in Cortical Neurons.

Melissa Plooster, Guendalina Rossi, Martilias S Farrell, Jessica C McAfee, Jessica L Bell, Michael Ye, Graham H Diering, Hyejung Won, Stephanie L Gupton, Patrick Brennwald

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Autoantibodies and Inflammation in Schizophrenia.Psychiatry and clinical neurosciences · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. A Functional Schizophrenia-associated genetic variant near thebioRxiv : the preprint server for biology · 2023
    Article
  14. Article
  15. Endosomal trafficking in schizophrenia.Current opinion in neurobiology · 2022
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Melissa PloosterDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599.
Guendalina RossiDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599.
Martilias S FarrellDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Jessica C McAfeeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.ORCID 0000-0001-8340-7153
Jessica L BellDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Michael YeDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599.
Graham H DieringDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599.ORCID 0000-0001-6113-6946
Hyejung WonDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Stephanie L GuptonDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599 pjbrennw@med.unc.edu sgupton@unc.edu.
Patrick BrennwaldDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599 pjbrennw@med.unc.edu sgupton@unc.edu.ORCID 0000-0001-9344-285X
University of North Carolina at Chapel Hill · USUniversity of North Carolina Health Care · US

Funding

REGULATION OF EXOCYTOSIS BY A RHO GTPPASER01GM054712 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI PATRICK J BRENNWALD · 1998 to 2026
$9.5M
Undergraduate Research: Coordinated Cytoskeletal Dynamics and Membrane Remodeling in Cellular Shape ChangeR35GM135160 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Gupton · 2020 to 2026
$3.3M
Deciphering Cell-type Specific Regulatory Landscape in Human BrainDP2MH122403 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WON, HYEJUNG · 2019 to 2019
$2.3M
Exocytosis fuels plasma membrane expansion in developing neuronsR01NS112326 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GUPTON, STEPHANIE · 2019 to 2023
$2.1M
Training in Mechanistic, Interdisciplinary Studies of Biological SystemsT32GM119999 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAMSDEN, DALE A · 2017 to 2021
$1.2M
Connecting gene regulatory mechanisms in human brain to psychiatric illnessR00MH113823 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WON, HYEJUNG · 2018 to 2020
$719k
The Genomics of Highly Treatment Resistant SchizophreniaK01MH108894 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FARRELL, MARTILIAS STEPHEN · 2016 to 2019
$567k
Determining the localization and function of schizophrenia-linked protein tSNARE1bF31MH116576 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PLOOSTER, MELISSA · 2018 to 2020
$100k
NIGMS NIH HHS R01 GM054712NIGMS NIH HHS R35 GM135160NIGMS NIH HHS T32 GM119999NIMH NIH HHS DP2 MH122403NIMH NIH HHS F31 MH116576NIMH NIH HHS K01 MH108894NIMH NIH HHS R00 MH113823NINDS NIH HHS R01 NS112326
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCerebral CortexEndosomesFemaleHumansMaleMiceMice, Inbred C57BLNeuronsProtein IsoformsProtein TransportRatsRats, Sprague-DawleySchizophreniaSNARE ProteinsProtein IsoformsSNARE ProteinsendocytosisGWASlate endosomeschizophreniaSNARE

Identifiers

PMID34642214
PMCPMC8580139
OpenAlexW3204987898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.