ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2021
Disentangling the symptoms of schizophrenia: Network analysis in acute phase patients and in patients with predominant negative symptoms.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Interrelationships of childhood trauma, psychiatric symptoms, neurocognition, and insomnia in chronic schizophrenia: a network perspective.European archives of psychiatry and clinical neuroscience · 2026Article
- Revealing differential psychotic symptoms in schizophrenia and bipolar I disorder by manifold learning and network analyses.Translational psychiatry · 2025Article
- Association between autistic features and empathy in Chinese patients with chronic schizophrenia.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Clinical presentation of first episode psychosis in people with and without HIV in KwaZulu-Natal, South Africa.Early intervention in psychiatry · 2025Article
- Pharmacological Treatments of Negative Symptoms in Schizophrenia-An Update.Journal of clinical medicine · 2024Review
- GDNF and miRNA-29a as biomarkers in the first episode of psychosis: uncovering associations with psychosocial factors.Frontiers in psychiatry · 2024Article
- Exploring core symptoms of alcohol withdrawal syndrome in alcohol use disorder patients: a network analysis approach.Frontiers in psychiatry · 2024Article
- Efficacy of behavioural activation in the treatment of negative symptoms in people with schizophrenia spectrum disorders: A systematic review.International journal of nursing studies advances · 2023Review
- Validity and reliability of a Chinese version of the self-evaluation of negative symptoms.Brain and behavior · 2023Article
- Symptom Structure in Schizophrenia: Implications of Latent Variable Modeling vs Network Analysis.Schizophrenia bulletin · 2022Article
- Depressive Symptoms and PANSS Symptom Dimensions in Patients With Predominant Negative Symptom Schizophrenia: A Network Analysis.Frontiers in psychiatry · 2022Article
- Prevalence, Influencing Factors, and Clinical Characteristics of Cognitive Impairment in Elderly Patients With Schizophrenia.Frontiers in psychiatry · 2022Article
- Primary and Secondary Negative Symptoms in Schizophrenia.Frontiers in psychiatry · 2021Review
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Abstract
backgroundThe Positive and Negative Syndrome Scale (PANSS) is widely used in schizophrenia and has been divided into distinct factors (5-factor models) and subfactors. Network analyses are newer in psychiatry and can help to better understand the relationships and interactions between the symptoms of a psychiatric disorder. The aim of this study was threefold: (a) to evaluate connections between schizophrenia symptoms in two populations of patients (patients in the acutely exacerbated phase of schizophrenia and patients with predominant negative symptoms [PNS]), (b) to test whether network analyses support the Mohr 5 factor model of the PANSS and the Kahn 2 factor model of negative symptoms, and finally (c) to identify the most central symptoms in the two populations.
methodsUsing pooled baseline data from four cariprazine clinical trials in patients with acute exacerbation of schizophrenia (n = 2193) and the cariprazine-risperidone study in patients with PNS (n = 460), separate network analyses were performed. Network structures were estimated for all 30 items of the PANSS.
resultsWhile negative symptoms in patients with an acute exacerbation of schizophrenia are correlated with other PANSS symptoms, these negative symptoms are not correlated with other PANSS symptoms in patients with PNS. The Mohr factors were partially reflected in the network analyses. The two most central symptoms (largest node strength) were delusions and uncooperativeness in acute phase patients and hostility and delusions in patients with PNS.
conclusionsThis network analysis suggests that symptoms of schizophrenia are differently structured in acute and PNS patients. While in the former, negative symptoms are mainly secondary, in patients with PNS, they are mainly primary. Further, primary negative symptoms are better conceptualized as distinct negative symptom dimensions of the PANSS.
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