SynthesisCritical care (London, England)2021
Predictive power of extubation failure diagnosed by cough strength: a systematic review and meta-analysis.
Synthesis in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Comparison of standardized diaphragm ultrasound measurement and conventional methods for predicting weaning failure: a prospective observational study.Journal of anesthesia · 2026Observational
- Liberation from Mechanical Ventilation in Acute Hypoxemic Respiratory Failure or Adult Respiratory Distress Syndrome: A Review.Journal of clinical medicine · 2026Review
- The Relationship Between Physical Activity Level, Respiratory Muscle Strength, and Cough Strength in Individuals with Type 2 Diabetes Mellitus: An Observational Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Article
- Association between abdominal muscle weakness and weaning failure in mechanically ventilated critically ill patients: an ultrasound assessment.Journal of anesthesia, analgesia and critical care · 2026Article
- Rethinking extubation readiness in the neurocritical patient: from respiratory load to airway protection.Intensive care medicine · 2026Article
- Diagnostic accuracy of tests for assessing readiness for liberation from mechanical ventilation in adults: an overview of reviews.Journal of intensive care · 2026Review
- Multi-view ultrasound for diaphragm monitoring and cough strength estimation.Communications medicine · 2025Article
- Feasibility of intratracheal tracheostomy sealing: anatomical adaptation and biocompatibility of a second-generation prototype in cadaveric and porcine models.Scientific reports · 2025Article
- Respiratory Evaluation in Spinocerebellar ataxia Type 2.Cerebellum (London, England) · 2025Article
- Assessments and exercises of cough strength in critically ill patients: a literature review.Journal of thoracic disease · 2025Review
- Investigating the risk of reintubation by cough force assessment using cough peak expiratory flow: a single-center observational pilot study.BMC pulmonary medicine · 2024Observational
- Effectiveness of high flow nasal cannula (HFNC) versus bilevel positive airway pressure (BiPAP) in preventing tracheal reintubation in patients with high risk of extubation failure in intensive care unit - A randomised comparative trial.Indian journal of anaesthesia · 2024Article
- Content analysis of NOC outcomes related to mechanical ventilation in people with COVID-19.Revista da Escola de Enfermagem da U S P · 2024Review
- Massive abdominal muscle atrophy during prolonged mechanical ventilation: Implications for tracheostomy removal.Journal of intensive medicine · 2024Article
- Sonometric assessment of cough predicts extubation failure: SonoWean-a proof-of-concept study.Critical care (London, England) · 2023Article
- Factors associated with extubation failure in an intensive care unit: a case-control study.Revista latino-americana de enfermagem · 2023Article
- Interpretable recurrent neural network models for dynamic prediction of the extubation failure risk in patients with invasive mechanical ventilation in the intensive care unit.BioData mining · 2022Article
- Weak cough is associated with increased mortality in COPD patients with scheduled extubation: a two-year follow-up study.Respiratory research · 2022Observational
- Observational
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe predictive power of extubation failure diagnosed by cough strength varies by study. Here we summarise the diagnostic power of extubation failure tested by cough strength.
methodsA comprehensive online search was performed to select potentially eligible studies that evaluated the predictive power of extubation failure tested by cough strength. A manual search was also performed to identify additional studies. Data were extracted to calculate the pooled sensitivity, specificity, positive likelihood ratio (LR), negative LR, diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC) to evaluate the predictive power of extubation failure.
resultsA total of 34 studies involving 45 study arms were enrolled, and 7329 patients involving 8684 tests were analysed. In all, 23 study arms involving 3018 tests measured cough peak flow before extubation. The pooled extubation failure was 36.2% and 6.3% in patients with weak and strong cough assessed by cough peak flow, respectively. The pooled sensitivity, specificity, positive LR, negative LR, DOR, and AUC were 0.76 (95% confidence interval [CI]: 0.72-0.80), 0.75 (0.69-0.81), 2.89 (2.36-3.54), 0.37 (0.30-0.45), 8.91 (5.96-13.32), and 0.79 (0.75-0.82), respectively. Moreover, 22 study arms involving 5666 tests measured the semiquantitative cough strength score (SCSS) before extubation. The pooled extubation failure was 37.1% and 11.3%, respectively, in patients with weak and strong cough assessed by the SCSS. The pooled sensitivity, specificity, positive LR, negative LR, DOR, and AUC were 0.53 (95% CI: 0.41-0.64), 0.83 (0.74-0.89), 2.50 (1.93-3.25), 0.65 (0.56-0.76), 4.61 (3.03-7.01), and 0.74 (0.70-0.78), respectively.
conclusionsWeak cough is associated with increased extubation failure. Cough peak flow is superior to the SCSS for predicting extubation failure. However, both show moderate power for predicting extubation failure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.