Evidence map›Paper›PMID 34641963›Full record

ArticleEuropean journal of medical research2021

Side-branch expansion capacity of contemporary DES platforms.

Alper Öner, Paula Rosam, Finja Borowski, Niels Grabow, Stefan Siewert, Wolfram Schmidt, Klaus-Peter Schmitz, Michael Stiehm

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Excessive Ostial Stent Protrusion: Evaluation of Management Strategies and Clinical Outcomes of the Side Flap Technique.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Article
  2. DES Selection for Left Main and Coronary Bifurcation Stenting.Reviews in cardiovascular medicine · 2023
    Review
  3. Drug-Eluting Stents: Technical and Clinical Progress.Biomimetics (Basel, Switzerland) · 2023
    Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alper ÖnerDepartment for Cardiology, Center for Internal Medicine, University Medical Center Rostock, Ernst-Heydemann-Straße 6, 18057, Rostock, Germany. alper.oener@med.uni-rostock.de.ORCID http://orcid.org/0000-0001-6116-7021
Paula RosamInstitute for Implant Technology and Biomaterials-IIB E.V, Associated Institute of the University of Rostock, Warnemuende, Rostock, Germany.
Finja BorowskiInstitute for Implant Technology and Biomaterials-IIB E.V, Associated Institute of the University of Rostock, Warnemuende, Rostock, Germany.
Niels GrabowInstitute for Biomedical Engineering, University Medical Center Rostock, Warnemuende, Rostock, Germany.
Stefan SiewertInstitute for Implant Technology and Biomaterials-IIB E.V, Associated Institute of the University of Rostock, Warnemuende, Rostock, Germany.
Wolfram SchmidtInstitute for Biomedical Engineering, University Medical Center Rostock, Warnemuende, Rostock, Germany.
Klaus-Peter SchmitzInstitute for Implant Technology and Biomaterials-IIB E.V, Associated Institute of the University of Rostock, Warnemuende, Rostock, Germany.
Michael StiehmInstitute for Implant Technology and Biomaterials-IIB E.V, Associated Institute of the University of Rostock, Warnemuende, Rostock, Germany.
Institute for ImplantTechnology and Biomaterials · DE

Funding

Bundesministerium für Bildung und Forschung RESPONSE "Partnership for Innovation in Implant Technology"
6 · The paper itself

Abstract

backgroundPercutaneous coronary interventions (PCI) of bifurcation stenoses are both complex and challenging. Stenting strategies share that the stents' side cells must be carefully explored and appropriately prepared using balloons or stents. So far, stent manufacturers have not provided any information regarding side-branch expansion capacity of their stent platforms.

aimsGiven that drug-eluting stent (DES) information regarding their mechanical capacity of side-branch expansion is not available, we aimed to evaluate contemporary DES (Orsiro, BIOTRONIK AG; Xience Sierra, Abbott Vascular; Resolute Integrity, Medtronic; Promus Premier Select, Boston Scientific; Supraflex Cruz, Sahajan and Medical Technologies) by their side-branch expansion behavior using in vitro bench testing.

methodsIn this in vitro study, we analyzed five commercially available DES (diameter 3.0 mm), measuring their side-branch expansion following inflation of different high-pressure non-compliant (NC) balloons (balloon diameter: 2.00-4.00 mm), thereby revealing the morphological characteristics of their side-branch expansion capacities.

resultsWe demonstrated that all tested contemporary DES platforms could withstand large single-cell deformations, up to 4.0 mm. As seen in our side-branch experiments, DES designs consisting of only two connectors between strut rings did not only result in huge cell areas, but also in larger cell diameters following side-branch expansion compared with DES designs using three or more connectors. Furthermore, the stent cell diameter attained was below the balloon diameter at normal pressure.

conclusionsWe recommend that the expansion capacity of side-branches should be considered in stent selection for bifurcation interventions.

Indexed as

Drug CarriersDrug-Eluting StentsHumansPercutaneous Coronary InterventionDrug CarriersBench testBifurcationMechanical loadRecoil

Identifiers

PMID34641963
PMCPMC8507243
OpenAlexW3205434760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.