ArticleBMC infectious diseases2021
Tuberculosis-Learning the Impact of Nutrition (TB LION): protocol for an interventional study to decrease TB risk in household contacts.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03598842 (Tuberculosis- Learning the Impact of Nutrition), which is not on this map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tuberculosis- Learning the Impact of Nutrition
Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Tuberculosis- learning about experience with nutritional supplementation (TB LENS): Perspectives on a nutritional supplementation for persons with TB and their household contacts.Global public health · 2025Article
- Enriching tuberculosis research by measuring poverty better: a perspective.BMC global and public health · 2025Review
- Article
- Food insecurity in South Indian households with TB during COVID-19 lockdowns and the impact of nutritional interventions: A qualitative study.PLOS global public health · 2025Article
- Determinants of transmission prevention behavior among Tuberculosis patients in Surabaya, Indonesia.Infection prevention in practice · 2024Article
- Intestinal Parasitic Infections May Be Overlooked Drivers of the Tuberculosis Pandemic.The American journal of tropical medicine and hygiene · 2024Article
- Successful treatment of tuberculosis using a collaborative approach between family and health workers.Journal of public health in Africa · 2023Article
- A micro-costing analysis of nutritional support for persons with TB and their families in India.Public health action · 2023Article
- Nutritional Supplementation Would Be Cost-Effective for Reducing Tuberculosis Incidence and Mortality in India: The Ration Optimization to Impede Tuberculosis (ROTI-TB) Model.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Undernutrition is feeding the tuberculosis pandemic: A perspective.Journal of clinical tuberculosis and other mycobacterial diseases · 2022Review
- Avoiding pitfalls in calculating the population attributable fraction of undernutrition for TB.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022Article
- Assessing the Role of Pradhan Mantri TB Mukt Bharat Abhiyaan in India's Fight against TB: A National-level Data-based Research Investigation.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
Corrections and comments
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Authors and funding
20 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundComorbidities such as undernutrition and parasitic infections are widespread in India and other tuberculosis (TB)-endemic countries. This study examines how these conditions as well as food supplementation and parasite treatment might alter immune responses to Mycobacterium tuberculosis (Mtb) infection and risk of progression to TB disease.
methodsThis is a 5-year prospective clinical trial at Jawaharlal Institute of Post Graduate Medical Education and Research in Puducherry, Tamil Nadu, India. We aim to enroll 760 household contacts (HHC) of adults with active TB in order to identify 120 who are followed prospectively for 2 years: Thirty QuantiFERON-TB Gold Plus (QFT-Plus) positive HHCs ≥ 18 years of age in four proposed groups: (1) undernourished (body mass index [BMI] < 18.5 kg/m
conclusionsThis study will help determine whether undernutrition and parasite infection are associated with gene signatures that predict risk of TB and whether providing nutritional supplementation and/or treating parasitic infections improves immune response towards this infection. This study transcends individual level care and presents the opportunity to benefit the population at large by analyzing factors that affect disease progression potentially reducing the overall burden of people who progress to TB disease. Trial registration ClinicalTrials.gov; NCT03598842; Registered on July 26, 2018; https://clinicaltrials.gov/ct2/show/NCT03598842.
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