ArticleBMC infectious diseases2021
Mortality risk factors among hospitalized children with severe pertussis.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Variability in the Diagnostic Criteria for Severe Pertussis: A Systematic Review.JAMA network open · 2026Pooled it
- Pertussis infection in critically ill infants: meta-analysis and validation of a mortality score.Critical care (London, England) · 2025Pooled it
- Burden of pertussis in infants in the Eastern Mediterranean Region and the impact of maternal vaccination: a systematic review.BMC public health · 2025Pooled it
- Expert consensus on competency enhancement of pertussis prevention, diagnosis, and management for healthcare professionals through medical-preventive integration.Infectious diseases & immunity · 2026Article
- Cerebral venous thrombosis in infant with pertussis: A rare complication in a hyperleukocytosis and thrombocytosis Storm, A threshold worth defining.Hematology, transfusion and cell therapy · 2026Article
- Vaccination status and severity of pertussis among hospitalized pediatric patients at a tertiary center in Riyadh: an exploratory study.BMC pediatrics · 2026Article
- Early risk stratification for ICU admission in hospitalized children with pertussis: development and internal validation of an admission-time prediction model.BMC infectious diseases · 2026Article
- Early venoarterial extracorporeal membrane oxygenation with airway clearance techniques in severe pertussis with pulmonary hypertension in a two-month-old infant: a case report.International journal of emergency medicine · 2026Article
- The Ongoing Challenge of Pertussis in Eastern and Northern Europe: Recommendations from the Global Pertussis Initiative.Infectious diseases and therapy · 2026Review
- Epidemiological burden of pertussis in children in Asia: a review of 1990-2021 data and future projections.Translational pediatrics · 2026Article
- Risk factors for mortality in children with pertussis and hyperleukocytosis undergoing exchange transfusion: a single-center retrospective cohort study.Italian journal of pediatrics · 2026Article
- The Role and Safety of Aluminum Adjuvants in Childhood Vaccines.Pediatrics · 2026Review
- Parent-driven transmission, off-label SMZ-TMP, and severe pertussis prediction in infants under 2 months: a real-world observational cohort of 527 cases.Frontiers in pediatrics · 2026Article
- Successful azithromycin desensitization using a modified protocol after initial reaction: A pediatric case report.IDCases · 2026Article
- Clinical characteristics of pertussis in infants and risk factors for respiratory support.Annals of medicine · 2025Article
- The Bordetella type III secretion system effector BteA targets host eosinophil-epithelial signaling to promote IL-1Ra expression and persistence.Communications biology · 2025Article
- Retrospective analysis of 104 cases of pediatric severe pertussis in Southern China.BMC infectious diseases · 2025Article
- Clinical characteristics and prognosis of exchange transfusion in infants with severe pertussis.BMC pediatrics · 2025Article
- Clinical and immunological predictors of severe pertussis in children: a nomogram-based prediction model.BMC infectious diseases · 2025Article
- The Re-Emergence of Pediatric Pertussis: Insights from a Regional Romanian Hospital.Antibiotics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome children hospitalized for severe pertussis need intensive care; moreover, some children die because of deterioration alone or in combination with other complications. The purpose of this study was to identify the mortality risk factors among hospitalized children with severe pertussis.
methodsThis study evaluated the medical records of 144 hospitalized children with severe pertussis at the Guangzhou Women and Children's Medical Centre between January 2016 and December 2019.
resultsThe median age of patients was 2 months (IQR 1-4 months), with 90.3% of the patients aged < 6 months and 56.9% of the patients aged < 3 months. A total of 38 patients were admitted to intensive care unit (ICU), 13 patients died, and the mortality of severe pertussis was 34.2%, with patients younger than 6 weeks accounting for 76.9% of the deaths. On the multivariate analysis, the independent risk factors for death were WBC > 70.0 × 10
conclusionSevere pertussis mainly occurred in children aged < 3 months. The mortality of severe pertussis was 34.2%, with patients younger than 6 weeks accounting for the majority of the deaths. We recommend the first dose of diphtheria-tetanus-pertussis (DTP) should be advanced to the age of 2 months or even 6 weeks. The presence of a WBC > 70.0 × 10
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